1,485 search results for “brain models” in the Public website
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Innovative online course on Modelling and Simulation in Archaeology
Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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Stadium wave in the nerves: a new mathematical model
Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…
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Simone Dobbelaar
Faculteit der Sociale Wetenschappen
s.dobbelaar@fsw.leidenuniv.nl | +31 71 527 2727
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Linda van Leijenhorst
Faculteit der Sociale Wetenschappen
lleijenhorst@fsw.leidenuniv.nl | +31 71 527 3750
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Eduard Klapwijk
Faculteit der Sociale Wetenschappen
e.t.klapwijk@fsw.leidenuniv.nl | +31 71 527 2727
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Arko Ghosh
Faculteit der Sociale Wetenschappen
a.ghosh@fsw.leidenuniv.nl | +31 71 527 5123
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Simeen Tabassi Mofrad
Faculty of Humanities
f.tabassi.mofrad@hum.leidenuniv.nl | +31 71 527 2125
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Dominique van den Heuvel
Faculteit der Sociale Wetenschappen
dmheuvel@fsw.leidenuniv.nl | +31 71 527 6697
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Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…
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Spatial (3-D) CNS drug distribution in vivo
Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.
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BRAIN appoints University of Leiden as partner for BEC-Enabled production strain development
BRAIN Biotech and the Leiden University will jointly develop an Aspergillus based production strain with high yield and thus contribute to a bio-based circular economy. The cooperation is based on BRAIN´s molecular tool BEC.
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It is a myth that boys lag behind in brain development
It is true that girls perform better at school than boys, but this is not due to differences in brain development. This is the conclusion psychobiologist Lara Wierenga draws from a recent study. Publication in the Journal of Cognitive Neuroscience.
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European grant for Birte Forstmann to create an atlas of the Human Deep Brain
Deep-brain stimulation (DBS) is the most promising surgical treatment for movement and neuropsychiatric disorders, but is accompanied by unwanted side effects. Birte Forstmann, professor by special appointment, has been awarded a ERC Proof of Concept Grant to create an atlas of the human deep brain…
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Elseline Hoekzema investigates the impact of pregnancy on the human brain with European grant
Neuroscientist Elseline Hoekzema receives a large European grant from the European Research Council (ERC). This ERC starting grant for promising young researchers allows her to investigate the effects of pregnancy on the brain in detail.
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Burning brain questions of young people bundled in new research agenda
During ExpeditionNEXT in Middelburg, NeurolabNL youth, together with researchers from Leiden University and Erasmus University, handed over a unique research agenda to NWO Chairman Marcel Levi. In it, young people share what they would most like to learn about themselves and the brain.
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Fewer errors in software features by using delta modelling
When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…
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Daredevil behaviour of young people due to active reward centre in the brain
Young people tend to take more risks than children or adults. This trend is related to the reward centre in the brain, which is much more active when they are rewarded, PhD candidate Barbara Braams discovered. Personality, testosterone levels and social context also play a role in risk-taking.
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Interactive models: Matthijs van Leeuwen receives NWO TOP grant
Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…
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Child abuse from generation to generation: what role does the brain play?
‘We didn’t find any mechanisms in the brain for transmitting child abuse from generation to generation. What we did find is that experiences of neglect and abuse affect the brain differently,’ concludes Lisa van den Berg (Clinical Psychology). PhD defence 30 June.
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Double inaugural speech: how social context influences processes in the brain
It’s not a regular occurrence at Leiden University: two professors giving their inaugural lecture on the same day. Berna Güroğlu and Ellen de Bruijn specialise in related disciplines: they both research the influence of social context on processes in the brain – Güroğlu in adolescents and De Bruijn…
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Novel system-inspired model-based quantum machine learning algorithm for prediction and generation of High-Energy Physics data
Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.
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Founding father of pharmacological models
After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.
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Review paper on the potential impact drug-metabolizing enzymes on brain exposure
PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.
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XXY versus autism: evidence from neuroimaging
Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI
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A look at music in the brain at the LIBC public symposium
How does music affect a test subject’s brain? That was just one of the questions on the minds of the people who came to the LIBC public day to hear Rebecca Schaefer’s talk, as well as to hear from other top researchers about their investigations into music. The five woodwind players in the Calefax reed…
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Bibi van den Berg about the Dutch brain drain in Cyber security
Bibi van den Berg, Professor of Cyber Security Governance at the Institute of Security and Global Affairs (ISGA), has been interviewed by Financieel Dagblad (FD) and BNR Nieuwsradio about the considerable shortage of cyber security specialists in the Netherlands. Van den Berg warns of a brain drain,…
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using population pharmacokinetic and physiology based pharmacokinetic modeling approaches
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Leiden archaeologists create open educational resources on agent-based modeling
The past two years, Laura van der Knaap and Professor Karsten Lambers worked on creating open teaching materials on agent-based modeling, funded by Erasmus+ and in collaboration with Danish, Irish and Dutch partners. Programming is an important skill involved in this, which is often seen as intimidating…
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These researchers turn mathematical models into healthcare solutions
Two Leiden researchers have demonstrated how mathematics can improve our healthcare. Daniel Gomon has developed a model that contributes to the quality of care in hospitals. Marta Spreafico works on an app that helps physicians make well-informed decisions about the treatment of a certain type of cancer.…
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may have made the essential difference in the evolution of our huge brain
Hunter-gatherers acquire their food through complex gender-specific foraging techniques for a relatively stable and diverse supply of energy. New research indicates that this specialisation by boys and girls starts at a very young age. Most likely, this enabled the human species to evolve much larger…
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Young thinkers pit their brains on the circular economy
How can we speed up the transition from large cities to a circular metropolis? This is the question that Leiden students and former students Elsemieke, Fabian and Eveline are getting their teeth into. They and seventeen other young academics are taking part in the National ThinkTank and they have four…
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Sebastiaan Deetman
Science
s.p.deetman@cml.leidenuniv.nl | +31 71 527 5616
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Mirko Forastiere
Science
m.forastiere@cml.leidenuniv.nl | +31 71 527 2727
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Ruben Huele
Science
huele@cml.leidenuniv.nl | +31 71 527 FLEX
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Learning from small samples
Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…
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Visualizing cityscapes of Classical antiquity
This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.
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Winner of the Model Gamification Contest
Dave R. Stikkolorum, Michel R.V. Chaudron, Oswald de Bruin won the Best Paper Award of the Model Gamification Contest at the ACM/IEEE Models 2012 Conference for their paper: The Art Of Software Design, a Video Game for Learning Design Principles.
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New flowchart to eliminate Universe models
Cosmologists have many possible models for the Universe, of which only one can be true. A new flowchart will eliminate some of them when two specific Universe features are accurately measured. Publication in Physical Review D on 7 November.
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Strings and AdS/CFT at finite density
Promotor: Prof.dr. J. Zaanen, A. Parnachev
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Franco Donati
Science
f.donati@cml.leidenuniv.nl | +31 71 527 4571
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Bioactivity based quality control for Chinese herbal medicine
Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?
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Nanoparticles: shapeshifters that pass along the food chain and end up in the brain
Nanomaterials can pass much further along the food chain than was previously thought. The particles can change shape and size in each organism, enabling them to pass on to the next one in the chain. Researchers from the Institute of Environmental Sciences discovered this accidentally when using a novel…
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Complexity Models to Prevent Financial Crashes
The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.
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Bruijn: ‘Hormonal fluctuations in women have been ignored for too long in brain research’
Psychologist Ellen de Bruijn studies the effects of hormonal fluctuations on behaviour and on the brain over a woman's life course. With an ERC Consolidator grant, she and 3 PhDs and a postdoc will further her EEG research on the different stages at which girls and women experience strong hormonal f…
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FOM Grant for Theoretical Model Majorana Gun
Professor Carlo Beenakker has been awarded a FOM Projectruimte subsidy to build a theoretical model of a majorana gun, a very promising instrument for quantum computers.
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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Fulco Scherjon
Faculteit Archeologie
f.scherjon@arch.leidenuniv.nl | +31 71 527 2727