Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

How was anti-communism organized in the West? New volume edited by Giles Scott-Smith, Luc van Dongen and Stephanie Roulin on the aims, arguments and associations of a range of transnational anti-communist activists during the Cold War.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Juurlink

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

The aim of this study was to provide insight into how teachers in higher education can be supported in the design, implementation and evaluation of group assignments by developing a theoretical and evidence-based framework for the design of group assignments.

This article investigates the efforts of influential Turkish Muslim civil society actors to amplify the voices of Muslim women in the Netherlands.

Can we tailor catalysts at the atomic scale by means of high-school chemistry and geometry rules?

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

In Dutch society’s discussions about remembering the colonial past, voice is often used as a metaphor for empowerment ('we must raise our voices'), whereas silence is often used as voice’s negative counterpart, signifying a loss or lack of power ('we will no longer be silenced'). Yet, silence is expressive:…

Do you want to know more about Cultural Anthropology and Development Sociology and what it is like to study in Leiden? Come to our online or on campus information events.

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

This book provides an overview of critical scholarly reflections on the history of Dutch slavery and colonization, as well as how this translates into critical cultural practices.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

In the present-day United States, to what degree(s) are far-right men and women similar and/or dissimilar in their motivating factors for engaging in far-right social movement activism?

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Source: Mol Psychiatry (2015)

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Promotor: A.P. IJzerman

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

PhD defence

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

Recently, the booklet 'Blended Learning, het versterken van het onderwijs op de Universiteit Leiden' has been launched. Sonja Wagenaar, educational adviser at ICLON, was project manager of the three-year Blended Learning Program in which blended learning training was implemented in the studies Psychology,…

Last Tuesday 20 February, the first Public Administration Alumniactivity took place, with the theme: Citizen participation in theory and practice. Carola van Eijk talked about her PhD Research 'Engagement of citizens and public professors in the co-production of public services.' Menno Spaan, founder…

Nematic liquid crystals form the key ingredients of most tv screens. The active version of these complex fluids forms a useful model for physicists to research the responses of active matter—like bacteria or traffic flows—to mechanical and geometrical cues. An international research team publishes their…

Children and adolescents really do use their ‘smart’ brain areas. This has been confirmed by an extensive and long-running study of the brain carried out by developmental psychologist Sabine Peters . Her findings can have important consequences for education. PhD defence 27 January.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Do you sometimes find yourself sweating in the classroom while your students are really relaxed? Do you find yourself answering your own questions more often than your students? Are your students mainly concerned with getting a good grade while putting in minimum effort?

With Leiden2022 drawing nearer, LeidenGlobal is busy developing extra activities to demonstrate the knowledge that is present in Leiden and to create interaction with a wider audience. With this valorisation, the partnership between several cultural and academic institutions in Leiden matches the theme…

Upcoming activities by ACPA PhD candidates Paul Houdijk, Gabriel Paiuk and Magda Dourado Pucci

Upcoming activities by docARTES candidates Tony Roe, Patrizia Bovi, Ned McGowan, Maximilian Haft and Nizar Rohana

Upcoming activities by PhDArts candidates Basma Hamdy, Danne Ojeda Hernandez and Joost Grootens

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

In this article, Yannick Veilleux-Lepage and Tommy van Steen, assistant professors at the Institute of Security and Global Affairs, discuss the degree of consensus within the field of terrorism studies regarding the impact of the COVID-19 pandemic on the activities of violent non-state actors.

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

Adolescents who were more popular among their classmates in junior school are often the ones who are more inclined to share things fairly with others. During this sharing process, 'social' areas of the brain are more strongly activated than in adolescents who are less popular. This is the finding of…

Just a few weeks until a festival full of exciting science activities bursts into life in Leiden. From January the city will be European City of Science for 365 days. Many researchers are enthusiastic participants. ‘I see it as an opportunity to help people feel the joy of discovering something new…

ACPA Professor Marcel Cobussen will participate in an international workshop on the development of an MA in Sound Studies at the University of Nantes.

Exclusion elicits the same response in children as in adolescents and adults. That is what psychologist Mara van der Meulen found when she studied brain activity in primary schoolchildren. ‘What is new for us is that it is the same in childhood as later in life.’ Doctoral defence on 10 December.