1,203 search results for “intellectuele property” in the Public website
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Diffuse, warm-hot extragalactic gas: predicting properties and detection with the EAGLE simulations
PhD defence
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Plundering of knowledge and territory
Industrialised countries mine raw materials in areas inhabited by Indigenous Peoples and appropriate the knowledge and culture of these peoples. Leiden anthropologists work to protect their rights.
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Group interests: rights of indigenous peoples
Industrialised countries extract natural resources in the territories of indigenous peoples, and appropriate the knowledge and culture of these peoples. Leiden anthropologists work to protect the rights of indigenous peoples. Their knowledge and advice enable governments to source sustainable produc…
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A new window on the Universe
Rottgering
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An empire of 2000 cities: urban networks and economic integration in the Roman Empire
The central aims of this project are to establish the shapes of the various urban hierarchies existing in the provinces of the Roman Empire and (especially) to use the quantitative properties of these hierarchies to shed new light on levels of economic integration.
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Institute of Private Law
The Institute of Private Law was closely involved in the development of Nieuw Burgerlijk Wetboek (the Civil Code of the Netherlands, which came about between 1948 and 1992). It has continued to fulfil this socially engaged role over the years. It also made a significant contribution to the development…
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Geometry in ornament: On the history, theory and science about the presumed universality of geometrical patterns and its cognitive foundation
Knowledge and culture subproject 3:
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Knowledge as world heritage
Researchers have the whole world as their work area. Dutch researchers collaborate with Chinese, Australians give lectures in Lithuania, Koreans move to America and back. Who can contribute to academic knowledge, who benefits from it and who pays for it? A fair and effective system for this has not…
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Research
PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Research Projects, Categories and Supervisors
These are the proposed research projects for LEAPS 2019. Please note that not all projects will go ahead and some may still be added in the near future. Final funding decisions lie with the Faculty sponsors. And please make a note that if you are interested in an ESA project, to check if your state…
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
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Synthesis
Abrupt Climate Change and Cultural Transformation
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Polyfluorinated bis-styrylbenzenes as amyloid-beta plaque binding ligands
Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Structure-reactivity relationships in glycosylation chemistry
In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Rethinking Markets in Modern India: Embedded Exchange and Contested Jurisdiction
Published on 26 February 2021.
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Reconstructive Description of Eighteenth-century Xinka Grammar
This dissertation presents a comprehensive description of Xinka, an indigenous language from southeastern Guatemala. The description is based on a missionary grammar that is titled Arte de la lengua szinca and was written by the priest Manuel Maldonado de Matos around 1773.
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Size effects in microstructured superconductors and quantum materials
We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.
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Approach to Markov Operators on Spaces of Measures by means of equicontinuity
The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.
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Understanding the role of mycorrhizas in global carbon cycle processes
How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?
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The vigilance of individuals
How, when and why the EU legislates to facilitate the private enforcement of EU law before national courts.
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Islamic courts and women's divorce rights in Indonesia: the cases of Cianjur and Bulukumba
This book presents the results of a research about the Islamic courts of Cianjur in West Java, and Bulukumba in South Sulawesi and the role they play in local divorce practices.
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United in incoherence – Private law concepts under pressure from European financial law
Just published: United in incoherence – Private law concepts under pressure from European financial law (in Dutch), in: Tijdschift voor privaatrecht 2017-4
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Bacterial glycomimetics: synthesis and applications
This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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The puzzle of protoplanetary disk masses
My work focuses on a class of astronomical objects called protoplanetary disks.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Reconstructing Magnetic Fields of Spiral Galaxies from Radiopolarimetric Observations
Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn
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Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes
Almost all bacteria are enveloped by a cell wall that provides cellular protection.
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Optimal decision-making under constraints and uncertainty
We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.
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Galaxy alignments from multiple angles
Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Untangling cosmic collisions: a study of particle acceleration and magnetic fields in merging galaxy clusters
On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Spatio-temporal dimensions of human-carnivore interactions in Chitwan National Park, Nepal
This is a joint PhD of the Faculty of Social and Behavioral Sciences at Leiden University and the Evolutionary Ecology Group at Antwerp University.
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Understanding protein complex formation: The role of charge distribution in the encounter complex
Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.
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Phylogenetic ecology of octocoral - gastropod associations
Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity, Nat. Commun., 2017
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…
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Algorithms for analyzing and mining real-world graphs
Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters
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The nature of evidentiality
This project launches a research program into the theoretical status and the terminological basis of evidentiality systems.
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Topological phases and phase transitions in magnets and ice
The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.
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Geometric approach to evolution problems in metric spaces
Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans