Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

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Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Supervisor: P.J.J. Hooykaas

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.

PhD defence

Flitsinterview met alumnus Kees van der Staaij: ik ben en blijf een jurist in hart en nieren

PhD defence

Due to its economic prosperity, its policy of (relative) religious tolerance, and its large numbers of migrants, the Dutch Republic has long had a reputation of being the prime example of ‘tolerance’, especially during the seventeenth century. Although the great variety of newcomers in the Dutch Republic…

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

Leila Demarest, Assistant Professor of African Politics at Leiden University, has recently been awarded with a Leiden University Fund research grant to study adolescents’ political attitudes and inter-group tolerance in Lagos, Nigeria.

If you follow the western media, you are likely to think of ‘Africa’ as the continent of origin of desperate migrants, a continent of hunger and disease and a breeding ground for international terrorism. But if you want to see the bigger picture, you should look no further than the African Studies scholars…

Stilzitten doet alumnus Bart Jansen niet graag. Zo geeft hij les in onder meer Nederland, Maleisië en Curaçao, houdt hij zich naast het recht ook graag bezig met kunst en mystiek en vindt hij naar eigen zeggen ‘alles wat fout gaat’ wel interessant aan de rechtsfilosofie. ‘Ik ben gek op veelzijdige mensen;…

An overview of Quantitative Pharmacology projects

Gubbens

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Waarom is empirisch-juridisch onderzoek van belang voor de rechtspraktijk en het wetenschappelijke onderzoek? Op die vraag kregen masterstudenten van de afstudeerrichtingen civiel recht, ondernemingsrecht en financieel recht antwoord tijdens het congres over empirisch-juridisch onderzoek en het privaatrecht…

In Nieuwsuur ging Michael Klos, docent/onderzoeker bij de Universiteit Leiden, ging bij Nieuwsuur in op ‘de Twitterfiles’.

Ontwerpers en onderzoekers gaan bij het verzamelen van data vaak uit van mannen als ze mensen bedoelen. Dat is onhandig en onveilig.

Onderzoekers van het Instituut Pedagogische Wetenschappen en de afdeling Jeugdrecht gaan samenwerken in 2 nieuwe onderzoeken: onderzoek naar het terugplaatsingen van kinderen na uithuisplaatsing en draagmoederschappen in Nederland.

Per 1 september 2021 is de stad Leiden een heuse stadscriminoloog rijker. Marianne Franken gaat in een vier jaar durend promotieproject onderzoek doen naar de veiligheidsbeleving van Leidse burgers.

SEO Amsterdam Economics and Leiden University’s Company Law department and Labour Law and Social Security department are to conduct an implementation assessment on the Dutch Whistleblower Protection Act (Wkb) on behalf of the Dutch Ministry of the Interior and Kingdom Relations.

Oud-studenten gingen op 30 augustus weer de collegezalen in om hun vaste plekje op de banken op te zoeken tijdens Leiden Revisited. Bezoekers konden genieten van inspirerende lezingen, maar ook van een gezellige borrel, buffet, en livemuziek.

On 9 and 10 November, the Institute of International and European Law of the University of Göttingen and the Minerva Center for Human Rights of the Hebrew University of Jerusalem, organized a conference called ‘Unpacking Economic and Social Rights: International and Comparative Dimensions’.

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Social science research helps us understand human behaviour and social structures. These are determined by various factors, which makes the research complex and increases the likelihood of drawing the wrong conclusions. The choice of research method and analysis is therefore extremely important. It…

Bones contain information about people’s lives such as where they came from, their age at death and which diseases they suffered from. Researchers can deduce a lot from them about a person’s life and about human evolution. This generates leads that could help solve present-day problems, such as how…

The ability to create objects and structures with our hands has been essential to human development. This ability is something modern society is at risk of losing. Leiden archaeologists gather knowledge about ancient processes of ‘making and creating’ over the centuries, knowledge that helps our current…

If a society is to be secure, sustainable and resilient, conflicting interests must be reconciled. Researchers at Leiden University study the behaviour of individuals, groups and states in relation to this issue, and use their knowledge to promote equality within and between communities.

Health is a wonderful gift, both for humans and for society. If we are able to prevent both physical and mental illnesses, we can spare a lot of suffering and fight rising health costs. Social scientists and physicians in Leiden are working closely together to conduct research on the human mental, behavioural…

The better teaching is for pupils and students, the more solid the basis will be that we give them for their future careers. This type of teaching requires strong instructors and insight into the best ways in which pupils can be supported, and research at Leiden University is making a contribution in…

Loopholes in international tax legislation contribute to the misuse of tax rules by multinationals. Leiden University legal experts investigate how the complex national and international tax rules can be made more consistent in order to create a better tax system.

This project involves research into the oeuvre of the Sundanese sculptor Iko, who has worked for the Catholic mission in Java and has carved sculptures for a chapel and church in Ganjuran. The images were designed by the Catholic layman Jos Schmutzer and are characterized by a fusion in style and symbolism…