All manuscripts submitted to Inter-Section need to adhere to these guidelines. Since 01-08-2022 Inter-Section uses APA7 as a reference system. Inter-Section therefore now follows the new Faculty of Archaeology guidelines concerning referencing and bibliography.

Hans Ulrich Scherer is Professor of Rheumatology, in particular Translational Rheumatology. He wants to build bridges between research and clinical practice and between departments and organisations at home and abroad. Scherer will give his inaugural lecture next Friday. ‘To make progress, we have to…

LUMC researchers are looking for factors that point to illness at an early stage.

Unraveling the immune-suppressive actions of drugs like prednisone.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

The research team

LUMC researchers are looking for factors that point to illness at an early stage.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Leiden PhD student Xuequan Zhou has designed a new promising molecule that efficiently kills cancer cells, but does not harm healthy tissue. The trick: the drug is only active when irradiated with light. Zhou’s new compound does this extra efficiently by cleverly self-organising into nanoparticles.…

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

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The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

Promotor: M.A.G.J. Orrit

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Promotor: Prof.dr. M. Danhof

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotores: J. Jonkers, K.E. de Visser

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Prostate cancer (PCa) is one of the most prevalent cancer in males.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

The Leiden University-European Center for Chinese Medicine and Natural Compounds (LUECCM) is a virtual research Centre bringing together research projects of many different researchers from different origin.

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.

Key publications of the Analytical BioSciences and Metabolomics group

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Control of infectious diseases poses continuous challenges for human health.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Eduard Fosch-Villaronga and Hadassah Drukarch from eLaw - Center for Law and Digital Technologies, recently published the book ‘AI for Healthcare Robotics’, published by CRC Press from Taylor and Francis Group in their AI for Everything Series.

Promotor: Prof.dr. J. Kuiper

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.