779 search results for “target therapy” in the Public website
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An online self-help programme for people with HIV and depressive symptoms
To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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New professor wants to improve care for sarcoma patients
Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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Sylvestre BonnetScience
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Webinar Transfusion Medicine and Cellular and Tissue Therapies
Study information
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Antithrombotic therapy in the Netherlands- New insights from nationwide data
PhD defence
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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Partners
Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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Information activities
Get to know us through our online events for prospective students!
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Stefano Coppola Receives AXA RF Fellowship to Study Pancreatic Cancer
Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.
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Biologics Formulation
A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…
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GMP facility for innovative drugs (KFT-J10 / IGFL)
The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.
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Career prospects
This Master enables you to practice professional activities such as: lead research projects and develop technically qualified projects in the field of transfusion medicine.
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Rare-earth nanoparticles in bioimaging and therapy
PhD defence
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Improving PTSD treatment for adults with childhood trauma (IMPACT-study)
The aim of this project is to investigate the (cost)effectiveness of two innovative forms of trauma-focused therapy for patients with childhood abuse related PTSD. The ultimate goal is to improve quality of care and contribute to treatment innovation for this severely ill target population.
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Projects
An overview of Quantitative Pharmacology projects
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Book Learn to Dare/DDD
In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…
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Clinical Psychology
Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Controlling anxiety in late life (CALL)
Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…
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Viral gene therapy approaches for CRB1 retinal disease
PhD defence
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In search of synergy: novel therapy for metastatic uveal melanoma
PhD defence
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Novel regenerative therapies for the adaptive immune system
PhD defence
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Immune modulation and monitoring of cell therapy in inflammatory disorders
PhD defence
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Clinical pharmacometrics to optimize immunosuppressive therapy in kidney transplantation
PhD defence
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Erik DanenScience
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
PhD defence
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Elise Dusseldorp: ‘Algorithms can see whom a treatment will work for’
Imagine how much time, money and discomfort it would save: a personalised treatment for each individual patient. Precision medicine like this is coming ever closer, thanks in part to Elise Dusseldorp’s algorithms. They retrieve a wealth of information from research data.
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Research Paradigms and Instruments
Our team is involved in the translation and adaptation of several questionnaires, for research purposes. Information about each questionnaire is listed below.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.
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Antibodies against rheumatic diseases tested directly on patients
Leiden Professor of Translational Rheumatology Hans Ulrich Scherer has one foot in the clinic, where he helps patients, and the other in the lab, where he supervises researchers. He bridges these two worlds in his hunt for autoimmune rheumatic diseases.
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One million euros grant for smart antibiotic combinations – tackling resistant infections and antimicrobial resistance
Optimised antibiotic combinations can combat bacteria more effectively while also slowing the development of resistance. Scientists from five European countries are joining forces to identify such combinations and provide tools for others to do the same. The project is led by Professor Coen van Hasselt…
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Registration Co-Align 2023
Registration for the Co-Align 2023 conference is open!
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
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Immunotherapy to limit atherosclerosis-projects
For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Therapeutic vaccine boosts survival rate in cervical cancer patients
A therapeutic vaccine against HPV-16 (type 16 human papillomavirus) improves the survival rate in cervical cancer patients. A new study by ISA Pharmaceuticals B.V. (a Leiden-based biotechnology company) and the Leiden University Medical Center (LUMC) shows that this vaccine produces a more robust response…