1,141 search results for “have screen” in the Public website
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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The use of Deep Learning in the automated detection of archaeological objects in remotely sensed data
Generally the data from remote sensing surveys - the scanning of the earth by satellite or aircraft in order to obtain information about it - is screened manually in archaeology. However, constant monitoring of the earth's surface causes a huge influx of data of high complexity and high quality. To…
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Materials Innovative Technologies Assessment (MIN-TEA)
How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?
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The Cinematic Santri : Youth Culture, Tradition and Technology in Muslim Indonesia
The Cinematic Santri explores the rise and course over the last ten years of cinematic practices among a younger generation of NU associates (Nahdlatul Ulama), the largest traditionalist Muslim group in Indonesia and elsewhere.
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Diagnosis and treatment of obese children with insulin resistance
Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst
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Projects
Research projects
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Nursing mothers' rooms Pieter de la Court Building
Pieter de la Court, Wassenaarseweg 52, 2333 AK, Leiden
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Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice, Nat. Chem. Biol. 2020
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Artificial metallo-proteins for photocatalytic water splitting: stability and activity in artificial photosynthesis
Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Word as Image: Waka Inscription on the Folding Screen at the Turn of the 17th Century in Japan
Lecture
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LCA of Printed and E-paper Documents
Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.
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What we have done, how, and why
The Food citizens? team has included two post-docs, three Ph.D. candidates and two research assistants working with the Principal Investigator. The Winter School involved nine Masters and Ph.D. candidates from the universities of Bologna, Gothenburg, Kaunas, Leiden, Louvain, Tromsø, Turin and Utrech…
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Scientists have most impact when they're free to move
An analysis of researchers' global mobility reveals that limiting the circulation of scholars will damage the scientific system.
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Application, selection and placement
Our selection and placement procedure starts with your application and ends with—hopefully—an invitation to you to enrol as an IRO student. This page tells you all you need to know about the steps to be taken in between.
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New theory on liquid crystals with high symmetry
LCD screens use liquid crystals which have a high degree of order, even though they form a fluid. A new theory maps out the interplay between order, temperature and symmetry. Publication in Physical Review X.
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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Application procedures exchange
To apply for an exchange or study abroad programme at Leiden University, you must first select the individual courses or projects you want to follow. Each of your course requests will then be evaluated by the relevant faculty. Once you receive faculty approval for at least 15 EC worth of courses or…
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Application procedure
The application procedure is broken down into three parts. Please keep in mind that you can apply only for one specialisation within the Political Science master’s programme.
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Application procedure
The application procedure is broken down into three parts. Please keep in mind that you can apply only for one specialisation within the Political Science master’s programme.
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Application procedure
The application procedure is broken down into three parts. Please keep in mind that you can apply only for one specialisation within the Political Science master’s programme.
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Application procedure
The application procedure is broken down into three parts. Please keep in mind that you can apply only for one specialisation within the Political Science master’s programme.
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Application procedure
The application procedure is broken down into three parts. Please keep in mind that you can apply only for one specialisation within the Political Science master’s programme.
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Making big data meaningful for a promising start
All children deserve a promising start. Most children are doing fine. But some need extra support, because of problems during pregnancy or because they grow up in disadvantaged circumstances, e.g. due to poverty, parental addictions or psychological problems.
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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A metabolomics resistance test
Can metabolomic profiling be used to predict resistance against insect herbivores in plants?
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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MENA Cultures and Global Aesthetics
Aesthetic formations and cultural repertoires give meaning to our reality in ways that are never neutral. Focusing on the Middle East and North Africa (MENA) and its global interlocutors, this project brings together a team of scholars from Leiden University who bring in inter-disciplinary, inter-area…
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Solid Bioneedle-Delivered Influenza Vaccines Are Highly Thermostable and Induce Both Humoral and Cellular Immune Responses
The potential of bioneedles to deliver influenza vaccines was investigated.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Slice of Science
The first photo of a black hole and measuring anxiety in the brain... From 13 until 22 May we're serving a free slice of science with your pizza.
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Bioactive Molecules in Microbial Sciences
Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
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Solutions for CRitical Raw materials - a European Expert Network 2 (SCRREEN2)
How can Critical Raw Material policies/strategies be enhanced in the EU context?
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Imagined Voices- A Poetics of Music-Text-Film
Imagined Voices deals with a form of composition, music with on-screen text, in which the dynamic between sound, words and visuals is explored.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro
Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.
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Data mining and algorithm development
Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…
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Programme structure
The master's specialisation Occupational Health Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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À la carte education - Faculty of Humanities
If you are interested in an academic programme, but do you not wish to complete the entire programme? Then, you can choose one of the many à la carte courses the Faculty of Humanities offers.
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Programme structure
The master's specialisation Child and Adolescent Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.