Which metabolites of sponge are influenced by individual environmental or biological factors?

‘We’re going to see each other again on campus. We’re so pleased, but we do have to say safe.’ Rector Magnificus Hester Bijl is looking ahead to the new academic year, which begins on 6 September. No more 1.5m distancing, but we do have to take responsibility for other people’s safety.

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

The researchers at the Institute of Education and Child Studies focus on child rearing and the development of children and adolescents with and without developmental and other problems, in biological and non-biological families, childcare, education and care institutions.

Research at the SBC group is comprised of the following research themes:

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

The Biological- and Soft-Matter Physics Master specialisation is one of the two programmes Leiden offers in experimental Physics. The programme can to a high degree be tailored to individual needs and interests.

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Promotor: Prof.dr. J.N. Kok

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

The research in Biological- and Soft-Matter Physics specialisation consists of 120 European Credit Transfer System (EC) points and includes electives (60 EC) and two research projects (60 EC).

Leonie Vreeke is ready to start a new 5-year project to develop a stepwise treatment specific to very shy young children. Her proposal was granted by ZonMw with nearly € 600.000,-. A PhD student and a research assistant will be appointed to execute this project, together with societal partners such…

PhD defence

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

How does it feel to be spied on by robots? Did you know that they too discriminate? Our entanglement with technology makes life easier, but there’s a downside too. Artists and researchers will show all aspects of this in the SAILS online talk show The Future of AI is Human. Join in on Tuesday 15 December…

The quality of the care for our senior citizens could be improved. With an eye for the biological, social and management aspects, this Master’s programme provides important insights for improvements. The Master’s in Health, Ageing and Society starts you thinking, puts you to work and gives direction…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Where did species survive the cold cycles of the current Ice Age?

Key publications of the Biologics Formulation group

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Supervisor: Gerard van Westen

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

School of pharmaceutical sciences, University of Geneva - Switzerland

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Professor at the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria - South Africa

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The Biological- and Soft-Matter Physics specialisation is an excellent preparation for pursuing a PhD degree in physics.