PhD defence

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

PhD defence

Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.

The research within the Food research programme at CML focuses on a transition towards sustainable food production and consumption systems. We investigate from a very small to a very large scale, at a local, national or international level. We do so by researching for example molecular tools, food systems,…

Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…

In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…

Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.

Projects in the department of Environmental Biology

Did early farmers deliberately use animal manure on their fields?

Since the adoption of agriculture people have cultivated fields. The project concerns all kinds of aspects related to raising crops.

A special relationship between plants and fungi, which plays an important role in carbon storage in soil, has the potential to slow down climate change. However, the amount of carbon stored in soil is decreasing as a result of human activity. This is what researchers say in a publication in Nature Communications.…

The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.

Stratigraphy, Palaeoenvironment and Archaeology of the Middle and Late Pleistocene Deposits.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

PhD defence

Inaugural lecture

The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…

PhD defence

PhD defence

What are the key issues in conducting LCA of bioenergy systems? What is the environmental sustainability status of second generation bioethanol? How much would the final results of biogenic carbon neutrality assumptions deviate from the true values based on a complete inventory? How to assess the impact…

PhD defence

PhD defence

PhD defence

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

Today’s socio-economic challenges aren’t new. In the centuries after the retreat of the Roman state people with different backgrounds and with different ways of life somehow managed to build and maintain a complex economic system in northern Gaul that would produce the ruling dynasties of Europe. By…

How can we quantify the density of species within a community through environmental DNA concentrations?

Biodiversity is under pressure worldwide, but is essential for our health, food security and well-being. What is the influence of human actions on ecosystems? Can we provide biodiversity-inclusive solutions for our key societal challenges? These questions are central to the Biodiversity research the…

Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.

'Skill, craft, and poiesis-intensive innovation' is written by Cristina Grasseni and is published in FormAkademisk.

Agrian History, 5300 BC - AD 1000; C.C. Bakels

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

The book ‘Pesticides and the Environment’ gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Promotor: Prof.dr. G.P. van Wezel

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

In late medieval and early modern times, books, as well as the people who produced and read (or listened to) them, moved between regions, social circles, and languages with relative ease. Yet, in the multilingual Low Countries, francophone literature was both internationally mobile and firmly rooted…