817 search results for “soil barrier” in the Public website
- OSCoffee: Open Science in Criminology - barriers and opportunities
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Food
The research within the Food research programme at CML focuses on a transition towards sustainable food production and consumption systems. We investigate from a very small to a very large scale, at a local, national or international level. We do so by researching for example molecular tools, food systems,…
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead
On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Annual report CML 2016
In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…
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Ecotox
Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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Imaging the (un)imaginable of the Barrier Immune System
PhD defence
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Professor and Knight: Joke Bouwstra Receives Royal Honor
A memorable farewell symposium and a royal distinction: Professor Joke Bouwstra could not have completed her career at Leiden with more pleasure. On Friday, 14 June, she received a Royal Honor from Leiden Mayor Peter van der Velden, who appointed Bouwstra as a Knight in the Order of the Dutch Lion for…
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Anna van Buerenplein
Anna van Buerenplein 301, The Hague
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Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.
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Knowledge from now
Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.
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Plant Sciences
The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…
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Biodiversity
Biodiversity is under pressure worldwide, but is essential for our health, food security and well-being. What is the influence of human actions on ecosystems? Can we provide biodiversity-inclusive solutions for our key societal challenges? These questions are central to the Biodiversity research the…
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Institute of Environmental Sciences (CML): best institute for quantitative environmental issues
A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.
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The use of animal manure by prehistoric and early medieval farmers
Did early farmers deliberately use animal manure on their fields?
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Tilling and manuring prehistoric and early historic fields in western Europe
Since the adoption of agriculture people have cultivated fields. The project concerns all kinds of aspects related to raising crops.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
- GeoArch Leiden
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A fatty solution for eczema
Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.
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Research projects launched into biodiversity in food and horticulture production
Two Leiden research projects that focus on increasing the biodiversity of Dutch production systems for food and ornamental horticulture have started thanks to funding from the Dutch Research Council's KIC research programme.
- ELS lab meeting - Journal Club: What went wrong? Methodological barriers to ELS by Jessie Pool
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Holocene Paleoenvironmental Evolotion of a Perimarine Fluviatile Area
Geology and Paleobotany of the Area surrounding the Archaeological Excavation at the Hazendonk River Dune (Western Netherlands).
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Maastricht-Belvédère
Stratigraphy, Palaeoenvironment and Archaeology of the Middle and Late Pleistocene Deposits.
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Spatial (3-D) CNS drug distribution in vivo
Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.
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Open Science Monitor – Study on Open Science: monitoring trends and drivers
The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.
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LMUY
Einsteinweg 55, Leiden
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Gorlaeus Building
Einsteinweg 55, Leiden
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Together, plants and fungi could slow down climate change
A special relationship between plants and fungi, which plays an important role in carbon storage in soil, has the potential to slow down climate change. However, the amount of carbon stored in soil is decreasing as a result of human activity. This is what researchers say in a publication in Nature Communications.…
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Development of life cycle assessment for residue-based bioenergy
What are the key issues in conducting LCA of bioenergy systems? What is the environmental sustainability status of second generation bioethanol? How much would the final results of biogenic carbon neutrality assumptions deviate from the true values based on a complete inventory? How to assess the impact…
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Breaking Barriers, Personalizing Pathways - Psychological health and self-management of people with chronic kidney disease
PhD defence
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Over barrières en bruggen - Auto-immuunziektes op weg naar genezing
Inaugural lecture
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The quantum computer
The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
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Common Practice: a livelihood perspective of economic development in the post-Roman world.
Today’s socio-economic challenges aren’t new. In the centuries after the retreat of the Roman state people with different backgrounds and with different ways of life somehow managed to build and maintain a complex economic system in northern Gaul that would produce the ruling dynasties of Europe. By…
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Plant-soil interactions determine ecosystem aboveground and belowground processes in primary dune ecosystems
PhD defence
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interactions in Jacobaea vulgaris: zooming in and zooming out from a plant-soil feedback perspective
PhD defence
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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Institute of Biology Leiden
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
- Institute of Urban Environment
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Nature and human interactions
It is well-known that humans have significantly transformed ecosystems since their adoption of agriculture. However, in a deeper past, prehistoric hunter-gatherers may already have altered and modified their niche in ways that had major impacts on ecosystems.
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Pesticides and the Environment
The book ‘Pesticides and the Environment’ gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.
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Global distribution patterns of mycorrhizal associations
Mycorrhizas are symbiotic associations between soil fungi and most plant species.
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Fieldwork
Fieldwork is an essential part of this research and of course this part of the project is also a joint effort by citizen scientists and professional archaeologists. Discover when fieldwork will take place and how you can participate.