1,141 search results for “have screen” in the Public website
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Kinetic profiling of positive allosteric modulators of the mGlu2 receptor
Supervisor: Maarten Doornbos
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Transcript
As an Exchange or Study Abroad student you will receive an academic transcript from Leiden University which lists the courses you have passed, with grades and credits obtained.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Taught courses
When applying for exchange or study abroad at Leiden University, you will select the individual courses you want to follow and so create your own personal study programme.
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Lab facilities Clinical Neurodevelopmental Studies
Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.
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Contact
Interested in working with the Dutch Extract Library?
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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Dancing with the Stars
This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.
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Weekly Lectures
As a part of NVIC's film & lecture program, you can join a public film screening on Sundays at 7 pm, and a lecture on Thursdays at 6 pm. Seats are limited and we work on a first-come, first-serve basis. Our doors open 30 minutes in advance, and close 15 minutes after starting time or earlier in case…
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Yellow Lab
A 24 person classroom on the floor 0 of the Pieter de la Court building. Designed for groupwork, rolling, flexible tables and chairs are arranged around shared monitors. Each group has a small whiteboard. The frontal projection point has a short-throw projector with motion tracking and live annotation.…
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Development of thermostable lyophilized inactivated polio vaccine
The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.
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Strategy
The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.
- Medieval Book Scripts (5 ECTS)
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Tools and data
Overview of CML software and data
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Improvisations in phototrophy
Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.
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Endocannabinoids in health and stress
How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?
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Do banks have human rights?
On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.
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Having rights is better than equal treatment
Mohamed Tleis was born in Lebanon and studied there up to and including university. It was not an easy path because Tleis has to cope with a number of limitations: he has problems with both hearing and vision.
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Research
The Forensic Family and Youth Care Studies research group conducts innovative high-quality research aiming to gain knowledge about deviant developmental trajectories of vulnerable children, adolescents, and families, about how to prevent problematic development and how to intervene when necessary.
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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ReCNTR Screening: A Grain of Sand in the Mountain’s Belly
Arts and culture
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Sources
Increasingly, primary sources from the period before the emergence of digital media are being digitized. These “digital surrogates” have facilitated the work of (historical) researchers; instead of having to visit several archives, libraries and other places, the (primary) sources appear in front of…
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Our facilities
In support of the research and education, the Leiden Institute of Advanced Computer Science (LIACS) has a Research and Education laboratory at its disposal. Within this environment, we can offer machines that go beyond normal office automisation and production.
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LIBC Research Facilities
Research facilities within reach of LIBC members:
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
PhD defence
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Using functional genetic screens to understand and overcome PARP inhibitor resistance
PhD defence
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Vision and Imaging
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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Outreach and Science Communication
To strenghten ties with the public, press, other academics and wider society, LION employs an outreach officer.
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Visual Revolutions in the Middle East
Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Breaking the witches' spell: towards steering the soil microbiome for volatile-mediated control of the root parasitic weed Striga
Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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Research
Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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The importance of friendships in reducing brain responses to stress in adolescents exposed to childhood adversity: a pre-registered systematic
Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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PNEC-pro
PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel, and zinc based on biotic ligand models (BLMs).
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson