1,624 search results for “cell and” in the Public website
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Luca Giomi wins ERC Consolidator Grant for flowing cells
Theoretical physicist Luca Giomi receives a 2 million euro ERC Consolidator Grant for research into flowing cells in a strange hexatic phase, which is half fluid, half solid.
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Can an employer demand messages from a private cell phone?
The Netherlands Council of State ruled at the end of March that WhatsApp and text messages on the work and private cell phones of civil servants are considered to be official records. This decision puts the government in a difficult position. How are you going to store millions of texts and WhatsApp…
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Minute molecular movements might lead to more efficient biofuel cells
Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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Cell-based medicinal products: grant rejected, paper published
Cell-based medicinal products (CBMPs) belong to an innovative and heterogeneous group of medicines called advanced therapy medicinal products (ATMPs). The limited analytical toolbox for CBMP characterization and release testing is one of the reasons why CBMP development is so challenging.
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Christine Mummery
Faculteit Geneeskunde
c.l.mummery@lumc.nl | +31 71 526 9300
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Tessa Vergroesen
Science
t.m.vergroesen@biology.leidenuniv.nl | +31 71 527 4912
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Véronique Ongenae
Science
v.m.a.ongenae@biology.leidenuniv.nl | +31 71 527 5075
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Movements of steroid receptors inside the cell nucleus unraveled
Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.
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How our single-celled relatives package their DNA
A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.
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The Cell Observatory just got upgraded, and here is why
The European Commission has officially established Euro-BioImaging – which provides life scientists with open access to a broad range of technologies and resources in biological and biomedical imaging – as a European Research Infrastructure Consortium (ERIC). The Cell Observatory in Leiden is part of…
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The role of the interleukin 12 family in atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager
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Ewa Snaar-Jagalska
Science
b.e.snaar-jagalska@biology.leidenuniv.nl | +31 71 527 2727
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‘How can we translate the language of cells into cancer therapies?’
On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…
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New insight into immune cell behaviour offers opportunities for cancer treatment
An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Miraculous mechanism allows plant cells to directionally distribute the growth hormone auxin
Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…
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Spinoza Prize for Leiden cell biologist, immunologist and chemist Sjaak Neefjes
Sjaak Neefjes, Professor of Chemical Immunology at Leiden University, will receive the NWO Spinoza Prize this year. The Spinoza Committee called Neefjes an ‘exceptional researcher whose intelligence is matched by his boldness’. He will use the 2.5 million euro prize to pursue his research into cancer…
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Niko Tinbergen lecture 2019: Stem cells, mini organs and eternal life
Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.
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Quantum particles and bacteria without cell walls: KLEIN grant for Beenakker and Claessen
Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…
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Webinar Transfusion Medicine and Cellular and Tissue Therapies
Study information
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Erik Danen
Science
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Noortje Dannenberg
Science
n.dannenberg@biology.leidenuniv.nl | +31 71 527 5075
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forming embryo to cancer metastasis: the significance of collective cell movement
Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Joost Beltman
Science
j.b.beltman@lacdr.leidenuniv.nl | +31 71 527 4323
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Research
Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Correcting each other’s mistakes - why cells stuck together in early evolution
The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…
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Inexhaustible source of human heart muscle cells allows strong reduction of animal testing
Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mi
Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.
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T-cells more important in the fight against the COVID-19 virus than initially thought
A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…
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LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Real-time solid-state NMR spectroscopy inside living cells
Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…
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How cells determine the fate of proteins (and can we do it too?)
Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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It’s all about the cell wall for brand-new professor Dennis Claessen
Dennis Claessen has been appointed professor of Molecular Microbiology at the Institute of Biology Leiden. With his teaching and research on the cell wall, the professor wants to establish applications in the industry and the medical sector.
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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An overall picture: the environmental impacts of a new solar cell technology
A more efficient solar panel sounds great. But what if these new panels consume more toxic materials, or their production consumes a lot of energy? Leiden environmental scientists, together with colleagues from the Fraunhofer ISE, address this multifaceted question in a new publication in the prestigious…
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Caught in living cells: how bacteria regulate their genes to defend themselves
For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…
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EIC Pathfinder Challenge grant for research into autoreactive B cells in cardiovascular disease
At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.
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Roxanne Kieltyka in NRC: 'My dream is a gel for every cell'
Roxanne Kieltyka was interviewed for NRC and talks about squaramides, cell cultures and Goldilocks.
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Arthur Ram
Science
a.f.j.ram@biology.leidenuniv.nl | +31 71 527 4914