Promotor: A. Kros

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

Why does the past elicit this intense activity in the present? What does the past mean for the present, and what does it do to it? A WAR OF WORDS will engage this complex of Chinese claims to Manchu-Korean ancient history, South Korean reactions, public discourse and cultural expression in both states,…

Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…

Investigating the relations between Tupi Indigenous Knowledge, Museum Collections and the Dutch Colonization of Brazil

If Dutch cinema is examined in academic studies, the focus is usually on pre-war films or on documentaries, but the post-war fiction film has been sporadically addressed.

Saeedeh Shahnahpur defended her thesis on 13 September 2016.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

This book offers novel perspectives on the national and international dimensions of the post-war welfare state in Western Europe and North America.

Salvador Santino Regilme has been selected for a fellowship at the Netherlands Institute for Advanced Study (NIAS) in Amsterdam. From September 2022, he will spend 5 months at NIAS working on his research project titled 'The Normative Order of the Global War on Drugs'.

In this article, Ben de Jong, research fellow at the Institute of Security and Global Affairs, examines the relationship between double agents and their handlers.

Are you thinking about studying Crisis and Security Management: War and Peace Studies? Learn more and watch the videos.

The Revolt in The Netherlands erupted in 1566 and tore apart the Low Countries. In Memory Wars in the Low Countries, 1566-1700 Jasper van der Steen explains how public memories of the Revolt in the Habsburg Netherlands in the South and the Dutch Republic in the North diverged and became the objects…

Political scientist Corinna Jentzsch (Leiden University) about the organisation of rebel and government auxiliaries in the civil war in Mozambique (1976–1992).

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Tom Buitelaar is an Assistant Professor in the War, Peace & Justice programme of the Institute of Security and Global Affairs. This paper discusses four important challenges to the involvement of UN peace operations in international criminal justice: its effects on host state relations, peace and justice…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.

Japan's Occupation of Java in the Second World War draws upon written and oral Japanese, Indonesian, Dutch and English-language sources to narrate the Japanese occupation of Java as a transnational intersection between two complex Asian societies, placing this narrative in a larger wartime context of…

The Afro-Asianism of the early Cold War has long remained buried under the narrative of Bandung, homogenising and subverting the different visions of post-colonial worldmaking that co-existed alongside the Bandung project.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

Analysis of drug adversity

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

The historiography of the Bretton Woods conference of July 1944 is dominated by the personal clash between the principal negotiators, Harry Dexter White of the United States and John Maynard Keynes of Britain.

The path to rational drug and dose selection

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

In the last two decades, there have been heated public and scholarly debates in France, the United Kingdom, and the Netherlands on the violent end of empire. Nevertheless, the broader comparative investigations into colonial counterinsurgency tend to leave atrocities such as torture, execution, and…

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

A new government, conflicts around the world and obviously a lot of science: these are the five stories about Leiden University that you enjoyed reading in 2024.

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

High throughput microscopy

Promotor: A.P.IJzerman Co-promotor: A. Bender

In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.

In this article, Thomas Maguire, Assistant Professor at the Institute of Security and Global Affairs, examines why states use intelligence to influence external audiences.

Promotor: B. van de Water

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Does a drug enter into the human brain once administered in the body?

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

Supervisor: Lizi Xia

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?