1,990 search results for “hier throughout screening and microscopy” in the Public website
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COVID-crisis of COVID-kans? Adaptief en lerend bestuur in het LUMC en de regio
Covid-19 is een disruptieve ontwikkeling die hier en nu veel vraagt van zorgprofessionals, bestuurders en managers. Hoewel de crisis nog volop bezig is, is nu al duidelijk dat het Coronavirus een blijvende impact zal hebben op zorginstellingen en fundamentele vragen oproept over hoe we onze zorg optimaal…
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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New transmission microscope for low-energy electrons
Physicist Daniël Geelen has developed a new microscope that uses low-energy electrons. Those are less harmful to biological and organic materials. Geelen defends his PhD thesis on May 31st.
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Solution to distortion effect STM scanning
STM scanning experiments on poorly conducting materials are challenging, and can cause a distortion effect. A new model corrects for this effect, allowing physicists to better study materials in their quest to understand unconventional superconductivity. Publication in Physical Review B as Editor’s…
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Understanding the Surface Structure of Catalysts and 2D Materials at the Atomic Scale
The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.
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Futures Thinking
Discover the mixed classroom Futures Thinking offered by Honours Academy and learn how to prepare yourself as a professional for the future. Read more here.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Training and courses
There are several training oportunities within the cell observatory
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Should the VOG screening process be extended to include administrative fines?
Research shows that including administrative fines in the screening process for a Certificate of Conduct (in Dutch: VOG) is not currently feasible.
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Expertise
The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.
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Nanoplastics found throughout the human body – how worried should we be?
The world is becoming clogged with plastic, with tiny plastic particles found everywhere, from the oceans’ depths to the mountain tops, soil, plants, animals and even inside us. The question is: what harm, if any, are they causing? In a new article on The Conversation, environmental scientists Meiru…
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Screening enormous databases to find a cure for cancer
Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’
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Health, Ageing and Society (Msc)
Discover the master program Health, Ageing and Scoiety at Leiden University and contribute to a future proof health care system. Read more.
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Can we predict the future of ecosystems throughout the world?
To what extent does human intervention influence the world’s biodiversity? And can we predict how biodiversity and ecosystems will change in the coming years? Inaugural lecture by Peter van Bodegom, Professor of Conservation Biology, on 8 May.
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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Revolutie of zinsbegoocheling?
Wordt het nog wat met de Arabische lente?
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Corona waste kills animals throughout the entire world
Face masks and gloves designed to protect us are, in fact, dangerous for the animals around us. Scientists from Leiden warn that throughout the world, on land and in the water, animals are ingesting corona waste, or getting entangled in it. The two biologists are asking for everybody’s help to better…
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Better screening can help GPs recognise anxiety disorders earlier
Only one in five young people with emotional health problems such as an anxiety disorder receives appropriate professional help. GPs often fail to properly recognise the signals in children and young people, according to psychologist Semiha Aydin. How can we improve this? PhD defence 23 February.
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Meindert Lamers
Science
m.h.lamers@biology.leidenuniv.nl | +31 71 527 2727
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Merijn de Bakker
Science
m.a.g.de.bakker@biology.leidenuniv.nl | +31 71 527 5043
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Fons Verbeek
Science
f.j.verbeek@liacs.leidenuniv.nl | +31 71 527 5773
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Interactions in Designer Materials Unveiled
Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.
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History is a matter of a longing for rifles and flat screen TVs
History can be found in utensils and in interviews with ordinary citizens. ‘With the reconstruction of everyday life, an anthropological approach works better,’ thinks historian Jan-Bart Gewald. Inaugural lecture on 6 June.
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Platinum electrochemistry through a magnifying glass
In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.
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Low energy electron transmission through layered materials and chiral organic films
In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…
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Vacancies
On this page you can find the current vacancies at the Van der Molen research group.
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Microbial Chemotaxis
In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.
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Drug safety Sciences
Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.
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Smallest-ever Leiden University logo
The logo of Leiden University, with letters as small as a bacterium. Researchers from LUMC and the Institute of Biology have created the smallest logo of our university ever produced. It is a piece of fun with a serious real-world application: the new microscope with which the logo was made allows scientists…
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OMERO
From the microscope to publication, OMERO handles all your images in a secure central repository. You can view, organize, analyze and share your data from anywhere you have internet access. Work with your images from a desktop app (Windows, Mac or Linux), from the web or from 3rd party software. Over…
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Towards nano-MRI
By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Smartmix: A new generation of efficient biomedical research
Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?
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Core Facilities
Core Facilities are shared resources that provide access to instruments, technologies and services to researchers across the Institute of Biology. They are staffed by scientists with vast experience in their field, ensuring that all researchers can count not only on the latest available technology…
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Onze vroegste voorouders
De menselijke geschiedenis strekt zich ver uit vóór de tijd waarin de mensen opschreven wat er zoal gebeurde.
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Huub de Groot
Science
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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Microcoil MRI of Plants and Algae at Ultra-High Field: An exploration of metabolic imaging
This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).
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Subsidies for high-grade research facilities
Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Colloquium: Imaging Electrochemical Reactions by Operando Optical Microscopy
Lecture
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.