1,141 search results for “have screen” in the Public website
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Documentary Screening: Amigo Secreto (+ Q&A with the director)
Arts and culture, Screening
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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Start-Ups
The entrepreneurial spirit is highly present among the SBB students. The many (successful) spin-off companies from Leiden University brought by (former) SBB students are proof of this.
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Development of organ-on-a-chip systems for translational and personalized medicine
We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
- ISSC malfunctions
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Research
Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…
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Anxious in Beirut
This film will be screened on Sunday, 23 June 2024 at 7 pm.
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Studying and living in The Hague
The Hague is a real student city and has everything you’ll need to turn your time as a student into the time of your life.
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ReCNTR screening: Bo Wang, ‘An Asian ghost story’
Festival
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Protein Facility
The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Study and working conditions
Make sure you have a suitable place to work or study at home.
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Completed Studies
Below you can read about studies we have carried out in the past.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Newborn screening for severe combined immunodeficiency: Breaking the bubble
PhD defence
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Events
You'll be able to join us for a public film screening on Sundays at 8:00 pm and a public lecture on Thursdays at 8:00 pm (depending on the duration of the powercuts). Seats are limited and we work on a first-come, first-serve basis. Our doors open 30 minutes earlier and close 15 minutes later or when…
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Films: NVICinema
On some Sunday evenings the NVIC is presenting NVICinema. We bring a varied programme of Dutch or Flemish films, Egyptian classics as well as contemporary Egyptian feature films and short films from young talented directors, all with English subtitles.
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Facilities
Our facilities cover:
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Research Facilities
Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Control processes in children’s word productions
How does task context affect children’s word productions?
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Cultural activities
To reach a larger audience beyond the academy, a number of activities in the cultural realm have been programmed over the years.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Bone and joint disorders: Screening and early clinical drug development
PhD defence
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Tools and Data
Tools and Data of the department of Environmental Biology
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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Discovery of metastasis promoting candidate drug targets
Discovery of metastasis promoting candidate drug targets
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Infrastructure
An overview of our infrastructure at the SPP division:
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Collaborations
The Molecular Physiology group collaborates with both international public-private and academic institutions.
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Farm Excursion Nov 2022
In November we went to a real, biodynamic farm (Kwekerij Eko Logisch) and listened to David, a farmer who believes you can limit harm to the environment while still growing heaps of vegetables, fruits, and herbs. On the two-hour visit, we were shown around the farm and even encountered some animals.
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Imaging
The imaging group focuses on bio-imaging, image analysis and visualization.
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Human skin equivalent barrier optimization
The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.
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In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
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Activities
The CEES Centre regularly hosts (guest) lectures, roundtables, and film screenings.
- Summitry
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Receptor Residence Time
Research question