In this study, Tessa Dool and Thijs Bosker estimate the microplastic uptake of two odontocetes in the Mediterranean Sea and the Norteast Atlantic.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Lecture

Four Leiden researchers have been awarded Proof of Concept grants by the ERC. These grants, each worth 150,000 euros, help researchers translate the findings of previous ERC projects into innovative practical applications.

In the academic year 2023-2024 the SRS interdisciplinary programme will offer four courses for interested students who are entering the third year of their Bachelor's degree. You can sign up for these courses in your elective (minor) space. You can follow the courses individually as an elective, or…

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

On Monday 14 November, the first spadeful of earth was dug for the construction of the Living Lab, an experimental test site to study living organisms in freshwater. A total of 36 ditches will be dug out to create a natural environment where researchers can study the effects of chemical compounds from…

Can we improve the treatment of post-traumatic stress disorder (PTSD)? Our young and promising psychologist Rianne de Kleine receives a Veni grant to carry out her research on the treatment of post-traumatic stress.

How do nanoparticles bioaccumulate and biodistribute in organisms?

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How to improve the method in quantifying the combined effects of metal-based chemicals?

It is the dream of Professor Susana Chuva de Sousa Lopes to grow fertile egg cells in the lab. But she says there is a long way to go in her discipline until that is possible. This is the message of her inaugural lecture on 29 June 2020, the first digital inaugural lecture at Leiden University.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

Anne van Rongen has been honoured with the Wayne A. Colburn Memorial Award at the 2024 Annual Meeting of the American College of Clinical Pharmacology (ACCP). This highly regarded award recognises the best poster presentation, celebrating exceptional research and presentation skills.

When to launch a next-generation product in a competitive market and how much capacity should be allocated to it

PhD defence

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Software and Data of the department Industrial Ecology

Promotores: H.A. Udo De Haes, P.M. Brakefield

This study adds nuance to the empirical literature that interrogates the link between exposure to mass violence and post-conflict justice preferences.

On December 6th, Bob Schoemaker succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Bob on this great result.

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

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Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

In this article, Martin Sievert and Jonas Bruder investigated whether and how administrative burdens influences citizens' perceptions of welfare policies and attitudes towards beneficiaries.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Promotor: B. van de Water

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Promotor: T. Schmidt

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Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.