4,015 search results for “discovery of the year” in the Public website
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Reconstructing adhesives
An experimental approach to organic palaeolithic technology
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State, Society and Labour: A Social History of Iranian Textile workers, 1906-1941
This research investigates everyday lives and workplace experiences of Iranian workers employed at textile industry, which was the second biggest industry after oil following the latter’s discovery in 1908.
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Quan/Qual analysis of drugs and metabolites in biological matrices
Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?
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Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity, Nat. Commun., 2017
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…
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Scorescapes, On Sound, Environment and Sonic Consciousness
This doctoral trajectory explores sound, its image and its role in relating humans and our technologies to the environment.
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Orchestration of Distributed LOFAR Workflows
The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.
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Roman Republican Colonization
New perspectives from archaeology and ancient history
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Next444
The Next444 project focuses on the future of interdisciplinary research at Leiden University.
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AI-SUPPORTED SYNTHESIS OF SHEPARD-RISSET FREQUENCY SETS
Implementation of the new sound synthesis and analysis method in music composition.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Analecta Praehistorica Leidensia 39
Excavations at Geleen-Janskamerveld 1990/1991
- Leiden Academic Centre for Drug Research
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.
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A large-scale crop protection bioassay data set
ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Mind the gap: gas and dust in planet-forming disks
Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond
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Pattern mining for label ranking
Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe
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Learning to look at LiDAR: combining CNN-based object detection and GIS for archaeological prospection in remotely-sensed data
The manual analysis of remotely-sensed data is a widespread practice in local and regional scale archaeological research, as well as heritage management.
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A Grammar of Sunwar. Descriptive Grammar, Paradigms, Texts and Glossary
This grammar provides a description of Sunwar, a Tibeto-Burman language spoken in eastern Nepal, based on data collected during twelve months of field work.
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What is Citizen Science?
In citizen science projects, citizens and scientists work together to develop new scientific knowledge.
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In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
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LUECCM
The Leiden University-European Center for Chinese Medicine and Natural Compounds (LUECCM) is a virtual research Centre bringing together research projects of many different researchers from different origin.
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Research
Computers are becoming ever more powerful and are taking on more complex tasks. The Leiden Institute of Advanced Computer Science (LIACS) contributes to revolutionary scientific research and applies the latest inventions in the field, offering answers to today’s questions of society.
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Medical Biochemistry
Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
- Molecular Biotechnology
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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Career prospects
After graduation you have a lot of opportunities: academics are highly sought after in Dutch secondary education or mbo teaching. You can also aim for a management position or work as a researcher within the field of Life Sciences.
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Fundamental research on the voltammetry of polycrystalline gold
Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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Twenty years of countering jihadism in Western Europe: from the shock of 9/11 to ‘jihadism fatigue’
In this article, Jeanine de Roy van Zuijdewijn and Edwin Bakker provide a big picture reflection on two decades after 9/11 in Western Europe.
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New Year's resolutions? We'll help you out!
Work out more, eat healthier, have more time to yourself: we make resolutions every year, but they often don't make it past the end of January. To help you succeed this year, we have compiled a list with New Year's resolutions you can put into practice at the University!
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30 years and Professor: the story of Changsheng Wu
The death of his grandfather in 1988 motivates Changsheng Wu to become a scientist. In 2016, he is awarded the C.J. Kok Jury Award for his thesis on novel antibiotics. Two years later, he will become a Professor at Shangdong University, at the age of 30 years.
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Widespread cultural diffusion of knowledge started 400,000 years ago
Different groups of hominins probably learned from one another much earlier than was previously thought, and that knowledge was also distributed much further. A study by archaeologists at Leiden University on the use of fire shows that 400,000 years ago knowledge and skills must already have been exchanged…
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17 Years of The Hague Journal of Diplomacy in Numbers
The Hague Journal of Diplomacy - quantified! In our infographic below, we summarize the past 17 years in numbers.
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18 Years of The Hague Journal of Diplomacy in Numbers
The Hague Journal of Diplomacy - quantified! In our infographic below, we summarize the past 18 years in numbers.
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King Mario and the Holy Grail. Fifty years of European monetary integration
On Thursday 15 February 2018, the Hazelhoff Centre for Financial Law welcomed Roel Janssen, financial and economic journalist and writer, for the fifteenth Hazelhoff Guest Lecture.
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Faculty of Science starts new year with awards for talents
Mathematician Robbin Bastiaansen, physicist Irene Battisti, pharmacist Fouzia Lghoul-Oulad Saïd and physics and astronomy student Maite Boden are the winners of the annual prizes of the Faculty of Science. Boden was honoured as the first Young Star, a new prize for the best bachelor’s student of the…
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Student Ivana Nagtegaal's coronavirus year: 'We can be proud of ourselves'
In mid-March 2020, the global coronavirus outbreak changed everything in the Netherlands. Staying at home as much as possible and the 1.5 metre rule became the standard. One year on, we reflect on the past year with four Leiden Law School ‘insiders’. What kind of year did they have? And what are their…
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Postponement of the Congress on the Social Benefits of Higher Education to the autumn
The organising committee of the congress 'Social Benefits of Higher Education' has decided to postpone the congress.
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Two years on…
News from Food Citizens? Winter School alumnae
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Dead elephant was a feast for the entire neighbourhood
Former archaeology student Ivo Verheijen made a unique discovery in Schöningen in Germany: the almost complete skeleton of an extinct Eurasian straight-tusked elephant. The remains show that our ancestors enjoyed the odd elephant steak. But they weren’t the only ones…
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50 years of the Academic Language Centre: plus ça change?
That's just learning parrot-fashion. This was the argument with which the proposal to establish a language lab at Leiden University was rejected in 1962. But six years later, the language lab was launched. And now the Academic Language Lab is celebrating its 50-year anniversary.
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Opening of Academic Year on sustainability: optimism and criticism go hand in hand
The theme of the Opening of the Academy Year on 4 September was sustainability and how the university could take the lead as a change agent. How is it going about this and what else can it do? There was also room for a critical note.