The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

This master specialisation is ideally suited as a basis for starting a research career at a university or research institute and for a position in a bioscience-based company.

PhD defence

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

This network brings together scholars whose work explores how contemporary frameworks of crisis produce experiences of the present, rehash or disrupt established narratives of the past, and broker specific outlooks on the future. We collaborate in studying these crisis-scapes and exploring how they…

Inaugural lecture

This is an Erasmus+ International Credit Mobility project of ICLON (Leiden University Graduate School of Teaching) with four partners in Kazakhstan.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with two universities in Armenia.

The research in my group addresses a range of topics related to quantum many-body physics.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the University of Pretoria.

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

Obtaining imaging data is nowadays only the start of your project. Once the data has been acquired there are many things that still need to be done.

Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…

How can new compounds relieve cancer patients of severe side effects?

In the framework of his Jean Monnet Chair on Mobility and Security, Jorrit Rijpma has given a series lectures on EU migration and asylum law to the students of the interdisciplinary master on Governance of Migration and Diversity. This interdisciplinary master was set up in the framework of the Leiden…

On 12 January 2018 Jorrit Rijpma, associate professor of the Europa Institute and Jean Monnet Professor, held the yearly Meijers lecture. In the well-attended lecture he spoke on the topics of his Jean Monnet Chair on Mobility and Security: the aftermath of the refugee crisis and the effects on free…

On 9 February students of the Master in European Law visited the new headquarters of Eurojust, one of the EU’s agencies for judicial cooperation in criminal matters based in The Hague.

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

An overview of the courses

This book explores how ‘crisis’ - as a narrative, concept, grammar, and experience - structures time and space.

Scientific research on Colonialism and Slavery is done from different research programmes and different disciplines.

Duurzaamheid op de campus, energietransitie, groen, circulair

The work done by SUMO proteins in the cells of our body is of vital importance. Molecular cell biologist Alfred Vertegaal has been studying these proteins for nine years, first with a Veni subsidy and then with a prestigious Vidi subsidy.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

The LUCDH foster the development of new digital research by awarding a number of Small Grants each year. As in previous years the LUCDH received a large number of excellent grant applications for Research and Personal Development funds. Congratulations to the recipients of this year's research award…

Lecture, also on line with Zoom

PhD defence

PhD defence

PhD defence

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

John van Noort

Analysis of drug adversity

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

Cationic peptide amphiphile nanoparticles are employed for co-delivery of immune modulator CpG and antigen. This results in better targeting to the antigen presenting cells and eliciting strong Th1 response, which is effective against the intracellular pathogens.

High throughput microscopy

In the Life Science & Technology (LST) degree programme you study the functioning and applications of the living cell: the building block of all plants, humans, animals and micro-organisms. This can be your contribution to a clean and healthy world.