PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

The Leiden Institute of Physics has been awarded three out of twelve available grants from the FOM Projectruimte. Principal Investigators Milan Allan, Stefan Semrau and Carlo Beenakker all receive around 400,000 euro for their research.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

Featuring the world’s first neural synthesizer, artist Guy Ben-Ary and his collaborators will perform at the TodaysArt Festival in The Hague on 21 September. For this performance, he collaborated with the lab of Erik Danen to transform neural stem cells into neural networks on a chip.

A team of five PhD students from Leiden University is in the running for first prize in the Pharmacometrics Skills Competition. In a drug development simulation, they apply their mathematical pharmacological skills to solve clinical problems. On 24 March they will compete in the finals in Orlando, F…

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

Increased molecular knowledge of the mechanisms of processes in the cell can lead to better medicines or new methods for combating diseases. Our MSc students in Life Science and Technology (LST) specifically learn to understand the molecular and structural chemical and biological aspects of disease-related…

Four university medical centres, including the LUMC, are joining forces to increase pandemic preparedness in the Netherlands.

PhD defence

PhD defence

Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…

As a PhD candidate, you are expected to follow certain courses and training programmes in the context of your training as a researcher. The courses and training programmes will help you conduct your research, write your dissertation, develop your career, and gain self-insight. The LACDR PhD training…

A full overview of MacBio PhD Theses.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.

Tuesday May 24th, the LACDR Annual Spring Symposium was held.

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Our Talents and Discoveries was a yearly publication by the Faculty of Science of Leiden University, published since 2003. You can read all the editions online. Note that the original publication was in Dutch; the original title translates as 'What we are proud of'. The last booklet came out in 2022,…

PhD defence

The discovery in 2001 of the importance of microRNAs turned the world of molecular biology upside down. The small particles of RNA also attracted the attention of university lecturer Erno Vreugdenhil. Vreugdenhil: ‘Within five to ten years the first microRNA-directed medicines will come onto the mar…

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

He presented his PhD research entitled “Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling”. During his presentation, Rob highlighted the advancements he made in using zebrafish as model in system pharmacolog…

PhD defence

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

Source: J Cheminform, Volume 6, Issue 1 (2014)

Supervisor: Maarten Doornbos

Lecture

Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.

On this page you will find an overview of awards and prizes granted to our staff and students in 2024, as well as special appointments at Leiden University and other institutions.

In 2022, many of our staff and students won fantastic prizes and were awarded important research grants.

Connecting scientific fields, enhancing research and teaching, and providing innovative solutions to complex social issues: that is the idea behind interdisciplinary research. What did the university achieve in 2024? A small sample.

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

In order to stop a whole range of diseases or disorders at their source, you would have to be able to switch certain genes on or off. Sebastian Pomplun wants to develop substances that can do this very precisely. For example, he wants to disrupt cancer processes and make cells produce an important missing…

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

Helping cancer patients with treatment choices.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

PhD defence

PhD defence

PhD defence

PhD defence