How do macrophages and neutrophils contribute to metastatic onset?

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Synthetic cells, also known as artificial cells or protocells, have wide ranging applications from drug delivery vectors to cell models. In biotechnology they can function as micro- or nanoreactors with possible applications in biocatalysis and photocatalysis. Phospholipids are by far the most commonly…

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

Lecture

The IBL PhD and Postdoc Association, also known as IPPA, seeks to create a platform for PhDs and Postdocs at the Institute of Biology Leiden to interact with one another. IPPA arranges social gatherings approximately four times each year, which include food and drinks, with the goal of integrating PhDs…

The Board of Examiners consists of scientific staff members of the IBL, Naturalis Biodiversity Center and CML, who teach in the biology programmes. They are appointed by the Board of the Faculty of Science and act independently from the research institutes. The responsibilities of the board include…

Promotores: A.H. Meijer, H.P. Spaink

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: B. van de Water

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

The Biology and Education specialisation consists of 120 European Credit Transfer System (EC) points and consists of a Biology component (60 EC) and an education component (60 EC).

Afstudeerceremonie

Festival

What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Receiving welfare benefits has a major impact on criminal behaviour. This has been demonstrated by Marco Stam, who defended his thesis on 20 January 2022.

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

PhD defence

Afstudeerceremonie

PhD defence

Do you have questions about the specialisation Molecular, Cellular and Organismal Biology? Please contact us.

Do you have questions about the specialisation Evolutionary Biology? Please contact us!

The specialisation consists of 120 European Credit Transfer System (EC) points and consists of an Biology component (60 - 80 EC) and a science communication component (40 - 60 EC).

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

The Biology and Business Studies specialisation consists of 120 European Credit Transfer System (EC) points and includes a one-year biology component (60 - 80 EC) and a business component in the second year (40 - 60 EC).

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

Discovery of metastasis promoting candidate drug targets

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

There are several committees within the IBL that are crucial for organizing and coordinating research, education and finances. Among the lesser-known of these committees is the IBL Institute Council (IC or Instituutsraad, IR). The purpose of the IC is to serve as a link between IBL members and management…

The specialisation enables you to understand the fundamentals of management and entrepreneurship alongside high quality Biology research.

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

Source: Mediators Inflamm (2014)

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Organisation Institute of Biology Leiden

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

Searching for ways to delay the need for a transplant and trying to build kidneys to order.