1,961 search results for “site role” in the Public website
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Landscapes of Survival
Pastoralist Societies, Rock Art and Literacy in Jordan’s Black Desert (200 BC to 800 AD)
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Karahantepe: A New Pre-Pottery Neolithic Site in Şanlıurfa, Turkey
Lecture, Faculty Lecture
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Cheminformatics: Analyzing small-molecule activity data
While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.
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Transitional justice and liberal post-conflict governance : synergies and symmetries, frictions and contradictions
“Transitional justice” is a field of practice, policy and study that focuses on the ways that societies respond to legacies of large-scale atrocities though tribunals, truth commissions, reparations, and other mechanisms.
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Embracing the Provinces: Society and Material Culture of the Roman Frontier Regions
Embracing the Provinces is a collection of essays focused on people and their daily lives living in the Roman provinces, c. 27 BC-AD 476. It offers an overview of current research on Roman provinces and frontiers, deconstructing some long-held preconceptions and providing refreshing insights into unexplored…
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Sources
Increasingly, primary sources from the period before the emergence of digital media are being digitized. These “digital surrogates” have facilitated the work of (historical) researchers; instead of having to visit several archives, libraries and other places, the (primary) sources appear in front of…
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The Netherlands X-omics Initiative
The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.
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Pushing the envelope of nuclear magnetic resonance spectroscopy for paramagnetic systems
A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…
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Legitimacy in Multistakeholder Global Governance at ICANN
This article explores levels and patterns of legitimacy beliefs with respect to multistakeholder global governance at ICANN. From a large and systematic evidence base, Jongen & Scholte have found that ICANN has strong legitimacy underpinnings among its staff and board, as well as quite uniformly moderate-to-high…
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Death Revisited
The excavation of three Bronze Age barrows and surrounding landscape at Apeldoorn-Wieselseweg
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Play and Media
Play and Media is one of the six research themes of the LUCAS Modern and Contemporary cluster.
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A Disobedient Diaspora: Living Hinduism in Osdorp, Amsterdam
This project explores the religious lives of a Surinamese Hindu community practicing in Amsterdam at the Sri Radha Krishna Mandir from an interdisciplinary perspective.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Descendants and Ancestors: A study of Arabic inscriptions from the Arabian Peninsula (1st-4th c. AH/7th-10th c. CE)
On the 20th of October Abdullah Alhatlani successfully defended a doctoral thesis and graduated.
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Breaking and making the ancestors
Piecing together the urnfield mortuary process in the Lower-Rhine-Basin, ca. 1300 - 400 BC
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De la gloria al olvido
Estudio arqueológico de la primera ciudad española en la Tierra Firme de América: Santa María de la Antigua del Darién
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Matrilineal Islam: State Islamic Law and everyday practices of marriage and divorce among people of Mukomuko-Bengkulu, Sumatra, Indonesia
On 13 December 2023 Alf Farabi successfully defended a doctoral thesis and graduated.
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Reading Rubbish
Using object assemblages to reconstruct activities, modes of deposition and abandonment at the Late Bronze Age dunnu of Tell Sabi Abyad, Syria.
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Arabidopsis AGC3 kinases and PIN plasma membrane abundance
The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…
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Small molecule inhibitors of Nicotinamide N-Methyltransferase (NNMT)
NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…
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Towards artificial photosynthesis on the lipid bilayer of liposomes
Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.
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Hominin Evolution in Africa
The Great Rift Valley in Africa is a real treasure trove for discovering early human fossils. The fossils found in this part of Africa have determined our view of human evolution. But was the Great Rift Valley really the place where evolution took place or just a place where fossils are well preserved…
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Pre-Columbian social organisation and interaction interpreted through the study of settlement patterns
An archaeological case-study of the Pointe des Châteaux, La Désirade and Les Îles de la Petite Terre micro-region, Guadeloupe, F.W.I.
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Laminar Technology and the Onset of the Upper Paleolithic in the Altai, Siberia
The Altai region has yielded a cluster of Middle and Upper Paleolithic stratified sites that have been recently excavated using a multidisciplinary approach.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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The material semantics of the ‘palace of Mithridates’ in Samosata
Innovating objects in a Eurasian center of the Late Hellenistic period.
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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The Belgian epigraphic and archaeological mission at Shanhur
Update : August 2017 Dr Harco Willems
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Potential interference of fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.
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Adsorption and catalysis on Pt and Pd monolayer-modified Pt single crystal electrodes
The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Environmental Sciences
PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.
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The syntax and licensing of Gapping and Fragmenting
This study investigates the syntax and distribution of the two elliptical phenomena Gapping and Fragments, as well as the movements involved in ellipsis contexts in general.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Career preparation
In the ICCL programme we will provide you with the skills to work in as a legal professional in a global legal environment. Read more about career preparation.
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Reuvens
Reuvensplaats 2-4, Leiden
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The economic geography of Roman Italy
Can we identify different degrees of economic integration, both within and between regions, on the basis of archaeological proxies?
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Reactive Copolypept(o)ides as Novel Material for Systemic siRNA Delivery
The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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“The Waste of Society as Seen through Women’s Eyes”: waste, gender, and national belonging in Japan
Rebecca Tompkins defended her thesis on 21 March 2019
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Pre-Colonial and Post-Contact Archaeology in Barbados
This volume provides one of the most comprehensive overviews of the archaeology of a single Caribbean island yet published. Drawing together scholars from the Caribbean, north America and Europe, all working from a range of disciplines within the broader scope of archaeology, and drawing upon recent…
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The Pontine Region Project
The Pontine Region Project (PRP) is an on-going archaeological project that aims to study the long-term history of settlement and landscape in the Pontine region
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Therapeutic intervention to enhance atherosclerotic plaque stability
Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…
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Visualizing cityscapes of Classical antiquity
This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.
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Embedded Remembering: Memory Culture of the 1965 Violence in Rural East Java
Grace Leksana defended her thesis on 26 May 2020.