1,809 search results for “er al treatment discriminatie” in the Public website
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Clinical Neurodevelopmental Sciences Leiden University
The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.
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Dialogues as a Dynamic Framework for Logic
This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
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The neurobiology of depression and the relation between stress, mental health, ageing and chronic illness
I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
- Mathematical Institute
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Next444
The Next444 project focuses on the future of interdisciplinary research at Leiden University.
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Research
Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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The syntax of verbal pseudo-coordination in English and Afrikaans
This dissertation provides a systematic description of English and Afrikaans verbal pseudo-coordination and a formal analysis couched in the Minimalist program.
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa
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The Nandimitrāvadāna: A Living Text from the Buddhist Tradition
Ruixuan Chen defended his theses on 16 October 2018.
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Argumentation and rhetorics
Argumentation and rhetorics is the study of how we convince people verbally. In other words, what do people say and how do they say it?
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Algorithmic governance
Artificial intelligence could help make the work of public sector organisations, professionals, policy- and decision makers more effective, more efficient, and ideally could make it more rationalised and evidence-based.
- Leiden Academic Centre for Drug Research
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Yiatrosofia yia ton Anthropo: Indigenous Knowledge of Medicinal, Aromatic and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical
Promotor: Prof.dr. L.J. Slikkerveer
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Health, Medical and Neuropsychology
The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Projects
Research projects
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Research Design in Political Science: The new book by Dimiter Toshkov is now out
The new book by Dimiter Toshkov - associate professor of Public Administration at the Faculty of Governance and Global Affairs - has been recently published by Palgrave Macmillan.
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Invertebrate response to management of roadside edges
Does roadside management in the mid-west USA increase invertebrate diversity similar to practices in Europe?
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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The spiritual Tolkien milieu : a study of fiction‐based religion
Markus Davidsen defended his thesis on 16 October 2014
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Social Anxiety and Specific Phobia in youth
Welcome to the Social Anxiety and Specific Phobia (SASP) Research Group!
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Organisation
The programme group Clinical Neurodevelopmental Sciences is one of the six groups within the Institute of Child and Education Studies at Leiden University. The group participates in all stages of the education programme: the bachelor's, master's and research master's programme. The group is particularly…
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Desire for vengeance
What is the experiental content of desire for vengeance and how does it contribute to actual revenge?
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Welfare, social citizenship, and the spectre of inequality in Amsterdam
This article explores how notions of citizenship are negotiated in encounters between parents and youth care professionals in Amsterdam in the context of heated debates over citizenship and belonging. We draw on ethnographic research on Egyptian migrant parents’ interactions with the welfare state,…
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
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Medical Biochemistry
Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.
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The Tocharian Gender System: A Diachronic Study
On the 23rd of March, Alessandro del Tomba successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Alessandro on this achievement!
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Welfare and Inequality in Marketizing East Asia
Provides a cutting-edge comparative political economy analysis of welfare and inequality across ten East Asian countries.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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Antiviral Pharmacology
The focus of the Antiviral Pharmacology group led by Anne-Grete Märtson is optimizing antiviral therapy for different viral infections by conducting clinical trials and using innovative computational and dynamic laboratory methodologies.
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Research
Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.