2,891 search results for “equal treatment discrimination” in the Public website
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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The Cambridge Grammar of Classical Greek
This is the first full-scale reference grammar of Classical Greek in English in a century.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Development of life cycle assessment for residue-based bioenergy
Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Trade, Investment and Labour: Interactions in International Law
On 21 February 2019, Ruben Zandvliet defended his thesis 'Trade, Investment and Labour: Interactions in International Law'. The doctoral research was supervised by Prof. dr. N.J. Schrijver.
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Foreign investment in Africa
English The purpose of this research is to identify and examine the challenges faced by African States in the field of foreign investment with a view to contribute not only to the academic debate, but also to foster awareness and develop the capacities of these States with regard to the drafting, negotiation…
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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474, SCIENCE, 2017
The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…
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The Texture of the Lexicon
In this volume, Ray Jackendoff and Jenny Audring embark on a major reconceptualization of linguistic theory as seen through the lens of morphology. Their approach, Relational Morphology, extends the Parallel Architecture developed by Jackendoff in Foundations of Language (2002), Simpler Syntax (2005),…
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Research
Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Self-regulation in boys with ODD/CD
Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior
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Crime victims and the police
On 1 February 2018 Nathalie-Sharon Koster defended her doctoral thesis ‘Crime victims and the police’. The doctoral research was supervised by Professor J.P. van der Leun and M.J.J. Kunst.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Mechanisms of Ewing sarcoma metastasis: biochemistry and biophysics
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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A community effort to assess and improve drug sensitivity prediction algorithms
Source: Nature Biotechnology, Volume 2014, Issue June (2014)
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Transcutaneous vaccination by means of coated and hollow microneedles
Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.
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3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Studies in Armenian Etymology with Special Emphasis on Dialects and Culture
This dissertation provides an up to date description of the Indo European lexical stock of Armenian (ca. 500 entries) with systematic inclusion of unused data that are found in Armenian dialects.
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ADAPTED
The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…
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Yě yě yě - on the syntax and semantics of Mandarin yě
Zhaole Yang defended his thesis on 25 June 2020.
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De invloed van de woonplaats op de fiscale behandeling van grensoverschrijdende werknemers
On 14 November 2019 Niek Schipper defended his thesis 'De invloed van de woonplaats op de fiscale behandeling van grensoverschrijdende werknemers'. The doctoral research was supervised by Prof. S.C.W. Douma and Prof. J.P. Boer.
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Crime and Migration in an Age of Transformation
The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.
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Vocational identity of at-risk youth: tailoring to support career chances
How can mentors and social workers foster the vocational identity of at-risk youth and improve their prospects?
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Clinical Neurodevelopmental Sciences Leiden University
The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.
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Dialogues as a Dynamic Framework for Logic
This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
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The neurobiology of depression and the relation between stress, mental health, ageing and chronic illness
I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
- Mathematical Institute
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Research
Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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The syntax of verbal pseudo-coordination in English and Afrikaans
This dissertation provides a systematic description of English and Afrikaans verbal pseudo-coordination and a formal analysis couched in the Minimalist program.
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa
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The Nandimitrāvadāna: A Living Text from the Buddhist Tradition
Ruixuan Chen defended his theses on 16 October 2018.
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Argumentation and rhetorics
Argumentation and rhetorics is the study of how we convince people verbally. In other words, what do people say and how do they say it?
- Leiden Academic Centre for Drug Research
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Yiatrosofia yia ton Anthropo: Indigenous Knowledge of Medicinal, Aromatic and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical
Promotor: Prof.dr. L.J. Slikkerveer
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Health, Medical and Neuropsychology
The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.