Development of Natural Resource for New Medicines

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The Centre for Computational Life Sciences

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

The manner and context in which the government supports citizens' initiatives are often more important than the legal framework. In practice, it only creates unnecessary division and there are no solid grounds for it. Esmée Driessen, PhD candidate at the Department of Constitutional and Administrative…

The British police discovered 39 bodies in the back of a lorry earlier this month. The refrigeration unit in which the bodies were found had entered the United Kingdom via Belgium.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The League of European Research Universities (LERU) is a group of 24 leading European research universities.

This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

On Friday the 29th of October, LACDR presented highlights of its research and teaching program during an online Lunchtime Talk session at the European Medicines Agency (EMA).

The interdisciplinary Kiem project ‘Violence as a Population Health Problem’ has resulted in a plan to apply for a large, yet-to-be-decided research grant. The so-called pressure cooker session at the heart of the project proved very effective.

Which immune mechanisms are involved in host defense against Staphylococcal infection?

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Conference

Supervisor: Gerard van Westen

Leiden University seeks to bring knowledge, academic top talents, and resources from Leiden and China together in mutually beneficial joint research projects that are content-driven, based on existing excellent research.

The Van Bergen Fund aims to promote contacts between Dutch and international students in order to achieve a better understanding of each other's cultures. At the Symposium for Diversity and Inclusion the two winners of the Van Bergen Award 2015 were announced.

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

Fighting against cancer, antibiotic resistance and disposable plastics: Ahmed Ali, Fredj Ben Bdira, and Valerio Barbarossa receive a LUF grant for their innovative and socially relevant research. These grants for academic talent are often an important step towards grants by NWO and other grant insti…

In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…

An essential protein that regulates our heart beat turns out to be important for cancer cells as well. The discovery might open novel treatment strategies for fighting metastasis. Publication in Science Signaling on April 4th.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Over 170 SUNRISE’s stakeholders gathered on June 17-18 at the Academy Palace of Brussels, in connection with the EU Sustainable Energy Week, as one of the Energy Days. Renewable energy experts from Academia, Industry and Policy addressed the current state of the initiative and its priority research…

With cancer, the immune system is a double-edged sword: it can attack tumour cells, but can also help them grow and spread. It is a question of harnessing it. This is what Professor Karin de Visser argued in her inaugural lecture on 15 November 2019.

An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.

A full overview of MCBIM PhD theses.

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

In this work, we attempt to answer the question:

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Previous OSCL events and member initiatives include:

PhD defence

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Source: PLoS ONE, Volume 10, Issue 3 (2015)

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.