1,851 search results for “er al treatment discriminatie” in the Public website
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Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
PhD defence
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Defining optimal oncolytic virus treatment and diagnostics in high risk melanoma patients
PhD defence
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Treatment optimisation and pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
PhD defence
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In vitro models of bone-forming tumours: from target to treatment
PhD defence
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
PhD defence
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Nanoparticle-based combination drug delivery systems for effective cancer treatment
PhD defence
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Submission Guidelines
All manuscripts submitted to Inter-Section need to adhere to these guidelines. Since 01-08-2022 Inter-Section uses APA7 as a reference system. Inter-Section therefore now follows the new Faculty of Archaeology guidelines concerning referencing and bibliography.
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Archived
PhD Research Projects:
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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Topic: Novelty and enrichment
One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Choosing health: how do we encourage that?
Fundamental research teaches us how our brain decides to eat one more sweet, instead of doing exercise. A public information campaign about healthy lifestyle has little impact on the decision, as Professor of General Psychology Bernard Hommel is aware. However, he does know what works. But the question…
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Topic: Aging and neuropsychological rehabilitation
Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…
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Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
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Access & Support Platform
The Access & Support Platform is a network of disability experts by experience, i.e. staff and students, at Leiden University.
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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Localising global garment biographies
Discover the effects of clothing value and lifespan on buyer-user-producer relationships through collaborative research with Localising Global Garment Biographies.
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Chemical tools to monitor and control human proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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The magic of healing
In his book The magic of healing, Willem van der Does talks about 14 pioneers in the history of psychiatry. These pioneers all had one thing in common: they started with a radical idea which led to great enthusiasm.
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Related Party Transactions and Corporate Groups: When Eastern Europe Meets the West
On 1 April 2020, Ivan Romashchenko defended his thesis 'Related Party Transactions and Corporate Groups: When Eastern Europe Meets the West'. The doctoral research was supervised by Prof. S.M. Bartman en Prof. A. Radwan (Kaunas, Lithuania).
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Molecular mechanisms of adverse outcome and translational biomarkers
Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…
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LACDR PhD Portal
The objective of the PhD Education and Supervision program is to educate PhD candidates in becoming professionals who are competent to conduct scientific research in the field of the pharmaceutical sciences independently.
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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The Cambridge Grammar of Classical Greek
This is the first full-scale reference grammar of Classical Greek in English in a century.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Development of life cycle assessment for residue-based bioenergy
Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Trade, Investment and Labour: Interactions in International Law
On 21 February 2019, Ruben Zandvliet defended his thesis 'Trade, Investment and Labour: Interactions in International Law'. The doctoral research was supervised by Prof. dr. N.J. Schrijver.
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Foreign investment in Africa
English The purpose of this research is to identify and examine the challenges faced by African States in the field of foreign investment with a view to contribute not only to the academic debate, but also to foster awareness and develop the capacities of these States with regard to the drafting, negotiation…
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The Texture of the Lexicon
In this volume, Ray Jackendoff and Jenny Audring embark on a major reconceptualization of linguistic theory as seen through the lens of morphology. Their approach, Relational Morphology, extends the Parallel Architecture developed by Jackendoff in Foundations of Language (2002), Simpler Syntax (2005),…
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Research
Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Self-regulation in boys with ODD/CD
Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior
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Crime victims and the police
On 1 February 2018 Nathalie-Sharon Koster defended her doctoral thesis ‘Crime victims and the police’. The doctoral research was supervised by Professor J.P. van der Leun and M.J.J. Kunst.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Mechanisms of Ewing sarcoma metastasis: biochemistry and biophysics
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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A community effort to assess and improve drug sensitivity prediction algorithms
Source: Nature Biotechnology, Volume 2014, Issue June (2014)
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Transcutaneous vaccination by means of coated and hollow microneedles
Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.
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3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Studies in Armenian Etymology with Special Emphasis on Dialects and Culture
This dissertation provides an up to date description of the Indo European lexical stock of Armenian (ca. 500 entries) with systematic inclusion of unused data that are found in Armenian dialects.