How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

Jus post bellum, the body of laws and norms governing the transition from armed conflict to peace, has emerged as a crucial issue for international law scholars, governments, and all concerned with building a just and sustainable peace. The Jus Post Bellum Project, funded by the NWO and hosted by the…

Pharmacist-clinical pharmacologist Robert Rissmann has been appointed Professor of Translational Dermatology. This extraordinary professorship has been created jointly by the Leiden Academic Centre for Drug Research (LACDR) and the Centre for Human Drug Research (CHDR) to strengthen their partnership…

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

An important hormone excreting gland in the human body is the pituitary

During the 1980s and early 2000s, authors like Alex Schmid and Andrew Silke demonstrated the paucity of first-hand insights being used to study terrorism and the consequences this had for the reliability of the findings beings presented. But to what extent have these issues endured?

Professor Thomas Hankemeier and his international research team HYPERMARKER have received a 10m-euro grant from Horizon Europe and UK Research and Innovation.

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?

Lecture

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

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Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotor: M. Ubbink, Co-promotor: G. Siegal

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

Gerard van Westen and his group, together with pharmaceutical company Galapagos, start on developing software that invents new effective molecules. They will receive an NWO LIFT grant of 280,000 euros, of which 63,000 euros will come from Galapagos. The company will also bring its expertise in biology,…

The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

Life returned to something resembling normal after Covid but other crises soon took its place. These great challenges are also being felt at the University and our researchers are working on solutions. The nitrogen crisis, problems with young people’s services and an increasingly urgent climate crisis:…

Lecture

Division contact information & address

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

Life Sciences Artificial Intelligence Data Science

Russian military concepts developed in the late 19th and early 20th centuries still exist and have not lost their strategic relevance. The Russians used them to annex Crimea and are now applying them in the war in Ukraine. Although the concepts have been around for a long time, it does not mean they…

According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

The IBL represents the core of modern biological research at Leiden and we interact closely with the other life science Partner Institutes in the faculty:

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Supervisor: Andrea Martella

Promotor: A.P. IJzerman

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

As a student of Bio-Pharmaceutical Sciences, you have a strong interest in drug development: from the onset of diseases to the effects of individual drugs in the body. Is that true for you? Then, Bio-Pharmaceutical Sciences might be the right study programme for you!

Recently, Engin Yüksel gave a lecture on Russian military concepts from 1853 to the present day and his observations on the Russo-Ukrainian war at the Faculty of Humanities, premised on his recently completed doctoral research.

Lecture, PCNI Research Group State of the Art Meeting

The Russian invasion of Ukraine has also had dramatic consequences for Ukrainian students at Leiden University. Besides their intense concern about the fate of family and friends, they also face major financial problems. This also applies to Russian students who can no longer access their bank accounts.…

Ida Haisma has been appointed Director of the Leiden Bio Science Park. She will lead the transformation of the Leiden Bio Science Park from science park to innovation district. To this end, she will set up a new park organisation and act as the spokesperson for the park.