PhD defence

PhD defence

PhD defence

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…

The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…

The Drug Discovery and Safety specialisation consists of compulsory and optional components.

PhD defence

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

Voor zowel archeologen, paleontologen en geologen als vrijwilligers in de archeologie en paleontologie is het geen verrassing meer dat op de stranden van de Nederlandse kust fraaie vondsten gedaan kunnen worden. Vele artikelen, boeken, tentoonstellingen, congressen, lezingen, ‘zoekdagen’, krantenberichten,…

What practical knowledge do mentor teachers have of adaptive mentoring and of individual differences between student teachers?

PhD defence

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

Indira Nederpelt was elected as the winner of the Young Investigator Award for best oral presentation titled ‘’Kinetic characterization of clinically used GnRH peptide agonists’’.

Festival

PhD defence

Life Sciences Artificial Intelligence Data Science

PhD defence

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

On 16 May 2022, Professor Michel Wouters from the Department of Biomedical Data Sciences at the Leiden University Medical Centre (LUMC), will deliver his inaugural lecture titled ‘Quality of Cancer Care: why the real world matters’. Wouters will use the opportunity to describe how quality registries…

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

An essential protein that regulates our heart beat turns out to be important for cancer cells as well. The discovery might open novel treatment strategies for fighting metastasis. Publication in Science Signaling on April 4th.

The Phantom of the Ego is the first comparative study that shows how the modernist account of the unconscious anticipates contemporary discoveries about the importance of mimesis in the formation of subjectivity.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: Prof.dr. M.K. Richardson

This book covers the story of Greece and its central role in our understanding of European civilization, from the Palaeolithic era (400,000 BP) to the early modern period (1950 AD).

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Key publications of the Computational Drug Discovery group

Find out how to apply for Drug Discovery and Safety at Leiden University by following our step-by-step guide. NOTE: This specialisation will be integrated into the new specialisation ‘’Research in Bio-Pharmaceutical Sciences’’ as of September 2025.

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Do you have questions about the Bio-Pharmaceutical Sciences master’s programme or the specialisation Drug Discovery and Safety? Please contact us.

The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.