The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

John van Noort

Efficient gene-targeting during meiosis

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Promotor: Prof.dr. G.P. van Wezel

The research programme Probability Theory focuses on probability theory and on operations research.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Bruin

The research of the Algebra, Geometry and Number Theory programme ranges from fundamental mathematical theory to algorithms and applications.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

This book addresses the definition of history and how people are influenced by it.

PhD defence

PhD defence

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Subproject of

The research of the Algebra, Geometry and Number Theory cluster tries to bridge the gap between abstract theory and the world of algorithms and applications.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

The Death of Archaeological Theory, edited by John Bintliff and Mark Pearce, addresses the provocative subject of whether it is time to discount the burden of somewhat dogmatic theory and ideology that has built up over the last 25 years.

On the brink of war, what influences decision makers to attack another country? Using innovative theoretical angles, Femke E. Bakker explores whether the basic assumptions of democratic peace theory are indeed correct. She stresses the microfoundations of conflict, questioning the assumptions on…

Developing a method to simplify polynomials in complex curves

Majorana meets a mermaid

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Sentencing is becoming increasingly complex for the courts. Legal scholars and criminologists from Leiden document the process of sentencing in the Netherlands. They use this knowledge to advise legislators and those who implement this legislation on how to make sentencing more consistent and effect…

The master’s specialisation Algebra, Geometry and Number Theory at Leiden University is aimed at students who wish to acquire a profound knowledge of one of the areas within pure mathematics. There is a strong theme dealing with algebra and number theory as well as a strong theme dealing with topology…

Edited by linguists Jenny Audring (Leiden University) and Francesca Masini (University of Bologna), this is a unique handbook with a focus on morphology theories rather than morphological data. It covers a wide array of morphological theories, from traditional twentieth century models to current theoretical…

The focus of our theoretical physics research is the nature of macroscopic matter that is in one or the other way still in the grip of quantum physics.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Truth is stranger than fiction. In 1997 Juan Maldaceña discovered a remarkable dictionary that translates equation for equation the physics of black holes in string theory into the more conventional physics of quantum mechanics of interacting particles. The remarkable possibility exists that…

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

The master in Cultural Analysis: Literature and Theory at Leiden University studies contemporary literature and culture (art, cinema, pop music) from a theoretical, critical perspective, with special emphases on approaches developed in cultural and literary studies, feminist theory, phenomenology and…

Imitation is, perhaps more than ever, constitutive of human originality.

This political theory specialisation focuses on the concepts of legitimacy and justice—political philosophy’s core themes. Immersing yourself in theories, philosophical and theoretical methods, and complex cases, you will make the leap from opinion to analysis.