2,274 search results for “this week s discoveries” in the Public website
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Leiden Academic Centre for Drug Research
Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
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Molecular Physiology
Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Bio-Pharmaceutical Sciences (MSc)
The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.
- Time Seminar: Applications of Artificial Intelligence in Early Drug Discovery
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Research Handbook on Cross-Border Bank Resolution
This week has seen the publication of the Research Handbook on Cross-border Bank Resolution.
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H.L. Wesseling Fund
The Europa Institute has been the beneficiary of a generous grant from the H.L. Wesseling Fund. The Fund was established in memory of Professor Henk Wesseling (6 August 1937 – 18 August 2018), Dutch historian, Professor of contemporary history at Leiden University, and former rector of the Netherlands…
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Activities
The Leiden University Centre for Digital Humanities regularly offers events and workshops related to all aspects of digital humanities. Events are aimed at connecting scholars from across Leiden's Faculties with a research interest in all digital aspects of their chosen subject area.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Koenraad Schalm Group - String Theory and Experiment
Truth is stranger than fiction. In 1997 Juan Maldaceña discovered a remarkable dictionary that translates equation for equation the physics of black holes in string theory into the more conventional physics of quantum mechanics of interacting particles. The remarkable possibility exists that…
- Research
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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Doris Jacobs
Dr. Doris M. Jacobs, Lead Scientist at Unilever R&D, Wageningen, The Netherlands.
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On quantum transport in flat-band materials
The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.
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Annual Lectures
Since 2019, the Foundation for Austrian Studies organises an annual lecture in cooperation with the Institute for History.
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Non-linear astrochemical kinetics: theory and applications
This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Systems pharmacology-based translational drug pharmacokinetics
High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.
- About this minor
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Strategy
The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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Screening enormous databases to find a cure for cancer
Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’
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Malgieri's co-authored paper on PETs presented and published at FAccT Conference 2024
Gianclaudio Malgieri's paper entitled 'The unfair side of Privacy Enhancing Technologies: addressing the trade-offs between PETs and fairness', coauthored with Alessandra Calvi from Vrije Universiteit Brussel and Dimitris Kotzinos from Paris Cergy University, is set to be presented at this week's prestigious…
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What's China's comment?
On the 25th of February, Peng Wu successfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Peng on this achievement.
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Thousands of new students start an old-style EL CID
Smiling faces, a mass dance and a bit of awkwardness: after two ‘corona editions’ of EL CID, the Leiden introduction week is back with a vengeance this year. A total of 3,412 first-year students from Leiden University and University of Applied Sciences Leiden, accompanied by 486 mentors, started EL…
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‘We haven't finished with Tutankhamun's tomb yet'
Sensational, is how Leiden Egyptologist Olaf Kaper described the discovery of two new chambers in the tomb of pharaoh Tutankhamun. He hopes that a second set of scans will confirm their presence unequivocally.
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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PhD: Targeting electron transport chain in Listeria monocytogenes for novel antibiotic development
Science, Leiden Institute of Chemistry (LIC)
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‘A week feels like a month at the National Think Tank’
In the National Think Tank (NDT) 20 young academics spend four months reflecting on how to solve a societal problem. Four participants from Leiden told us about their experience.
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Tropical start to 55th edition of EL CID
Armed with sunglasses, a thick layer of sunscreen and several bottles of water, over 3,300 students have arrived in Leiden for their introduction week. The start of the 55th EL CID happened to be on the hottest day of the year.
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Webinars
On this page you will find a collection of presentations and videos of the Florence Nightingale Colloquia, seminars at the faculty and other event recordings hosted by the Data Science Research Programme.
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PhD Theses
A full overview of MacBio PhD Theses.
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Key publications
Key publications of the Predictive Pharmacology group.
- Admission & Application
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Binding kinetics
A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…
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Kroese-Duijsters Symposium 2024
The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The Kroese-Duijsters Symposia started in 2022 and we are pleased to invite you to the 3rd Kroese-Duijsters…
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Chemical tools to monitor and control human proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Met de voeten in het water
Publication on the excavations at Roman fort Matilo in Leiden
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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The international tax system as a complex system
Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…