The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

John van Noort

Efficient gene-targeting during meiosis

On 28 June 2018, Qiuyin Hu defended his doctoral thesis 'Regulating Working Conditions in Times of Globalization'. The doctoral research was supervised by Prof.dr. G.J.J. Heerma van Voss and Prof. dr. B. Barentsen.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

How does the development of digital technologies impact society, and law/regulation within that society?

What is the role of stress and stress-related hormones in emotion regulation?

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Promotor: Prof.dr. G.P. van Wezel

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

Promotor: P.M. Brakefield

The Faculty Board issued these Regulations of the Institute of Philosophy on 9 January 2018.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

More information on the PhD Regulations, Guidelines and Golden Rules.

The role of language in self-regulation and social behavior in children with an extra X chromosome

The PhD Regulations set out who is eligible to be a PhD candidate, what the tasks of the supervisor and co-supervisor are and which criteria the dissertation has to meet. The PhD Guidelines list the minimal requirements for the supervision, training and available facilities for PhD candidates.

What are the university's requirements for PhD candidates? How do you organise your PhD track? You read all about it in the regulations, guidelines and golden rules.

Promotor: J.M. Memelink

In a publication in Science, Noam Zelcer from the Division of Biopharmaceutics describes a previously unrecognized pathway to regulate LDL-cholesterol levels. He is also able to modulate this pathway. This opens the possibility for complementing and improving the efficacy of statins: A class of drugs…

PhD defence

PhD defence

The Leiden Risk & Regulation Lab serves as hub for excellent research in regulation and risk governance and acts a platform for engagement with the practice and education of regulation and risk governance. Specializing in risk governance, responsive and effective regulation, reputation and accounta…

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Children with autism spectrum disorder experience serious challenges in social functioning, which threatens their development in many areas of functioning.

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Procedures en reglementen met betrekking tot de cursussen en diensten van het Academisch Talencentrum. Regulations and procedures regarding courses and services of the Academic Language Centre

How can innovation help or hinder public procurement processes?

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

CERQ is a questionnaire measuring cognitive coping strategies developed by Dr. Nadia Garnefski and Dr. Vivian Kraaij.

In this article, Lydie Cabane, Assistant Professor at the Institute of Security and Global Affairs, discusses the emergence and diffusion of ‘global health’ as a concept. In addition to bringing a fresh perspective on the origins of global health, the paper contributes to the globalization debates by…

The research group Diplomacy and Global Affairs focuses on international diplomacy, international organisation, global, transnational, multi-level and comparative governance. Among key research topics are the European Union and the United Nations, EU current enlargement policy, rule of law in the EU,…

The topic of this PhD thesis is teachers' perspectives on self-regulated learning.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…