4,973 search results for “activism” in the Public website
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities
Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Surface Reactivity of Activated CO2 Selective use of energy in splitting CO2
Juurlink
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receptor ligand profiling reveals biased signalling and off-target activity, Nat. Commun., 2017
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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comprehensive and predictive theory of catalysis based on simple structure-activity relations
Can we tailor catalysts at the atomic scale by means of high-school chemistry and geometry rules?
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education: design, implementation and evaluation of group learning activities
The aim of this study was to provide insight into how teachers in higher education can be supported in the design, implementation and evaluation of group assignments by developing a theoretical and evidence-based framework for the design of group assignments.
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Intersectional activism: Dutch-Turkish Muslim women 'talking back' to securitization and Islamophobia
This article investigates the efforts of influential Turkish Muslim civil society actors to amplify the voices of Muslim women in the Netherlands.
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S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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Information activities
Do you want to know more about Cultural Anthropology and Development Sociology and what it is like to study in Leiden? Come to our online or on campus information events.
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Highly Efficient Activation of HCl Dissociation on Au(111) via Rotational Preexcitation
The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…
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The Future of the Dutch Colonial Past: Curating Heritage, Art and Activism
This book provides an overview of critical scholarly reflections on the history of Dutch slavery and colonization, as well as how this translates into critical cultural practices.
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Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Far-Right Activism: A Comparative Analysis of the Motivating Factors Driving Men and Women to Engage in Far-Right Social Movement Activism in the
In the present-day United States, to what degree(s) are far-right men and women similar and/or dissimilar in their motivating factors for engaging in far-right social movement activism?
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The interpretation of physical activity wearable data and its relation with metabolic and brain health in older adults
Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining β-Exoglucosidases In Situ and In Vivo
A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474, SCIENCE, 2017
The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…
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the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)
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particle uptake by dendritic cells is a key parameter for immune activation
Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…
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Controlling active matter with curvature
Nematic liquid crystals form the key ingredients of most tv screens. The active version of these complex fluids forms a useful model for physicists to research the responses of active matter—like bacteria or traffic flows—to mechanical and geometrical cues. An international research team publishes their…
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On shape and elasticity: bio-sheets, curved crystals, and odd droplets
Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.
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Positive feedback activates adolescent brain
Children and adolescents really do use their ‘smart’ brain areas. This has been confirmed by an extensive and long-running study of the brain carried out by developmental psychologist Sabine Peters . Her findings can have important consequences for education. PhD defence 27 January.
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Designing active teaching and learning
Do you sometimes find yourself sweating in the classroom while your students are really relaxed? Do you find yourself answering your own questions more often than your students? Are your students mainly concerned with getting a good grade while putting in minimum effort?
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Upcoming activities ACPA PhD candidates
Upcoming activities by ACPA PhD candidates Paul Houdijk, Gabriel Paiuk and Magda Dourado Pucci
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Upcoming activities by docARTES candidates
Upcoming activities by docARTES candidates Tony Roe, Patrizia Bovi, Ned McGowan, Maximilian Haft and Nizar Rohana
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Upcoming activities by PhDArts candidates
Upcoming activities by PhDArts candidates Basma Hamdy, Danne Ojeda Hernandez and Joost Grootens
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Predictions Regarding the Effects of the COVID-19 Pandemic on the Activities of Violent Non-State Actors
In this article, Yannick Veilleux-Lepage and Tommy van Steen, assistant professors at the Institute of Security and Global Affairs, discuss the degree of consensus within the field of terrorism studies regarding the impact of the COVID-19 pandemic on the activities of violent non-state actors.
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Accurate Probabilities for Highly Activated Reaction of Polyatomic Molecules on Surfaces Using a High-Dimensional Neural Network Potential: CHD3
An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…
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Leiden2022: a science festival bursting with activities
Just a few weeks until a festival full of exciting science activities bursts into life in Leiden. From January the city will be European City of Science for 365 days. Many researchers are enthusiastic participants. ‘I see it as an opportunity to help people feel the joy of discovering something new…
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Upcoming activity by ACPA Professor Marcel Cobussen
ACPA Professor Marcel Cobussen will participate in an international workshop on the development of an MA in Sound Studies at the University of Nantes.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Using a practical teaching model by beginning teachers learning to design lessons.
Beginning teachers often experience difficulties making activating lessons. This study investigates how and if the practical teaching model can offer them a hand in learning to design lessons.
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Elmer Maurits
Science
e.maurits@lic.leidenuniv.nl | +31 71 527 2727
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Hermen Overkleeft
Science
h.s.overkleeft@chem.leidenuniv.nl | +31 71 527 5037
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Riccardo Mancinelli
Science
r.mancinelli@cml.leidenuniv.nl | +31 71 527 2727
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Chenguang Gao
Science
c.gao@cml.leidenuniv.nl | +31 71 527 2727
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Kristell Penfornis
Faculteit der Sociale Wetenschappen
k.m.penfornis@fsw.leidenuniv.nl | +31 71 527 2727
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Dennis Hetterscheid
Science
d.g.h.hetterscheid@chem.leidenuniv.nl | +31 71 527 4545
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Health Day wins LUF Relationship-Promoting Activities Prize
Health Day has won the LUF Relationship-Promoting Activities Prize (LUF RAP). This 5,000-euro prize is awarded to an initiative by Leiden University students that brings the academic community together.
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William Michael Schmidli
Faculty of Humanities
w.m.schmidli@hum.leidenuniv.nl | +31 71 527 2341
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Need for active counterpower and greater transparency in local politics
The Hague City Council is discussing the implications for local politics of the verdict acquitting former councillors De Mos and Guernaoui of corruption. The court ruled that from a criminal law perspective there was no official bribery. The debate will mainly focus on whether De Mos' party ‘Hart voor…
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Utrecht: Unexpected allies and food activism in quarantine
This blogpost is a reflection of research assistant Marilena Poulopoulou on the food relief initiative she took part in between May and August 2020 in the city of Utrecht.