841 search results for “modelling simulations” in the Public website
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Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
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Modelling phonologization: Vowel reduction and epenthesis in Lunigiana dialects
This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.
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Interpreting lithic raw material variability in Middle Palaeolithic contexts
A modeling approach with applications to the Bau de l'Aubesier (Southeastern France)
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Néron models in high dimension: nodal curves, Jacobians and tame base change
We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Assessor-Centered Translation Quality Assessment: A Theoretical Model and a Case Study
Behrouz Karoubi defended his thesis on 15 June 2016
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Using computer simulations to discover where Neanderthals lived
Archaeologist Fulco Scherjon has used computer simulations to identify where and how Neanderthals lived in West Europe. What stood out was that they probably had lots of children and lived in smaller groups than was previously thought. PhD defence on 28 May.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Inventing anchors? The function of ‘Greek models’ within the process of innovation in Early Roman Drama
To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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Impact assessment modelling of matter-less stressors in the context of Life Cycle Assessment
Promotores: Prof.dr. G.R. de Snoo & Dr. R. Heijungs
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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‘Ūd Taqsīm as a Model of Pre-Composition
In this research project Nizar Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).
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Model-assisted robust optimization for continuous black-box problems
Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Digital Archaeology
Digital Archaeology is concerned with digital data for for archaeological research, and the computational methods and tools required to collect, analyse and manage it.
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Mathematical modeling of cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…
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underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Beth Lloyd
Faculteit der Sociale Wetenschappen
b.lloyd@fsw.leidenuniv.nl | +31 71 527 2727
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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ELIXIR Systems Biology Community
Making systems biology modelling a central pillar of research in biology
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Understanding membrane fusion at the molecular level using a biomimetic model system
How can the transport of molecules in living cells help to target medicines at exactly the right place?
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Dynamic real-time substrate feed optimization of anaerobic co-digestion plants
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)
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Teaching
Disseminating to the future generation of researchers the multidisciplinary working practices, expertise and scientific view that has been developed in research within the Plant BioDynamics Lab over the past years is an important objective in our collaborative efforts. The research papers of PBDL bring…
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Explaining Decision-Making in the European Union
Our project focuses on the analysis of decision-making processes in the European Union (EU) and explores how approaches and tools to understand decision-making found in both the Natural and the Social Sciences can be linked, knowledge between these traditions exchanged and synergies utilized. To explore…
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Seascape Corridors: How modelling routes through the sea can illuminate early island culture
What are the capabilities or limitations of traveling between islands and how does this reflect seasonal variation? Is it possible to show higher levels of connectivity between islands based on generated pathways between several sites on two separate islands?
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adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Through the hands of signers: modeling spread and change in historical sign language linguistics
The history of sign languages of deaf people is severely understudied. The historical linguistics of sign languages offers a fundamentally new perspective on the history of human languages. This project addresses the dearth of knowledge about historical sign language linguistics through a large-scale…
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Gerard van Westen: 'Our model predicts what candidate drugs do in your body'
He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…
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A New Model of Global Governance in International Tax Law Making (GLOBTAXGOV).
Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.
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Through the hands of signers: modeling spread and change in historical sign language linguistics
How do sign languages change and spread over time, and how is this influenced by their transmission history?
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European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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A monodromy criterion for existence of Neron models and a result on semi-factoriality
In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Probing the darkness: the link between baryons and dark matter
Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato
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‘Scientists should be careful when interpreting results of AI models’
Anthropologist Rodrigo Ochigame studies how AI is changing the practice of scientific research. From astrophysics to mathematics to climate science, they find that the adoption of new AI models is raising questions about what counts as reliable scientific evidence.
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Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Catherijne Knibbe
Science
c.knibbe@antoniusziekenhuis.nl | +31 71 527 6329
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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Vascular tumor of bone and related lesions; from gene fusions to tumor models
PhD defence