A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…

Promotor: Prof.dr. G.P. van Wezel

Patients share valuable advice and experiences with their peers in online patient discussion groups.

PhD defence

Cancer is one of the main causes of death in the Netherlands. Leiden researchers are working to improve the treatment of different types of cancer in order to increase the patient’s quality of life. A better understanding of how cancer develops will make it possible to deliver personalised and precise…

Researchers of the Leiden Institute of Advanced Computer Science (LIACS) have started a 4 year project on developing a system that sends out automatic alerts when components from engines are showing first signs of fatigue.

According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

Grants awarded to molecular physiology research

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…

How can Staphylococcus aureus bacteria subvert the host immune system?

IT lawyer Eduard Fosch Villaronga wants to promote diversity and inclusiveness in AI research. And that's really important, because he has observed how artificial intelligence - from Twitter to walking robots - is prejudice in terms of race, gender and sexual orientation.

The application procedure is broken down into three parts.

European product safety law is one of the focal points of internal market legislation.

Comparing terrorist attacks with falling off a step ladder is absurd, writes Jeanine de Roy van Zuijdewijn in NRC Handelsblad on 27 September 2017.

The Janssen-Cilag International N.V COVID-19 vaccine has received authorization for emergency use by the European Medicines Agency (EMA) on March 11. The vaccine was developed with fundamental support from the Molecular Virology group of the Leiden University Medical Centre (LUMC).

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Key publications of the Quantitative Clinical Pharmacology group

Key publications of the Quantitative Pharmacology group

The LACDR represents the core of bio-pharmaceutical research at Leiden University, and we interact closely with our partners:

Key publications of the Predictive Pharmacology group.

Research question

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Pharmacy undergraduate education at Leiden Pharmacy combines the strong scientific foundation of the bachelor programme Bio-Pharmaceutical Sciences with experience-based learning and a strong focus on pharmaceutical patient care and pharmaceutical treatment in the master programme Pharmacy.

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

The Faculty of Governance and Global Affairs of Leiden University in The Hague has developed two Serious Games, 'het Grote Migratiespel' and 'het Schipholspel' to introduce secondary school students to their study and research programmes.

Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Promotor: Prof.dr. M.K. Richardson

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

What are the functions of the endocannabinoid system?