1,967 search results for “dynamical systems” in the Public website
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Understanding membrane fusion at the molecular level using a biomimetic model system
How can the transport of molecules in living cells help to target medicines at exactly the right place?
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Slaves To The System: Researching North Korean Forced Labor in the EU
SLAVES TO THE SYSTEM: Locating Responsibility for Forced Expatriate Labour Practices by the Democratic People’s Republic of Korea (DPRK)
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Random walks and the contact process
Promotores: W. Th. F. den Hollander, M.O. Heydenreich
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policy-making; the contribution of think tanks to policy advisory systems
Think tanks have proliferated in most Western democracies over the past three decades and are often considered to be increasingly important actors in public policy. Still, their precise contribution to public policy remains contested.
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Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems
On 14 November 2019, Luis Fiallos Pazmino defended his thesis 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. The doctoral research was supervised by Prof. P.M.J. Mendes de Leon and Prof. E.C.P.D.C. De Brabandere.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Bram Klievink: 'The government’s biggest AI challenge is that no system is ever neutral'
Using artificial intelligence is more complicated for the government than for companies. Bram Klievink, Professor of Public Administration, aims to identify the problems and find solutions.
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Semigroups on Spaces of Measures
Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille
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Applications of paramagnetic NMR spectroscopy for protein research
The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.
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About the programme
The Applied Mathematics Programme consists of 120 European Credit Transfer System (EC) points. The programme consists of advanced courses (min 60 EC), a research project (40 EC) and electives (max 20 EC).
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Programme structure
The research specialisation offers you the opportunity to spend two full years on training in applied mathematics to become an independent scientist with a strong theoretical basis.
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Polypept(o)ide-based Cylindrical Polymer Brushes as Multifunctional Drug Delivery Systems
The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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sentencing: a homicide case flow analysis of the Dutch criminal justice system
Homicide engenders broad moral concerns in society, and its aftermath can be understood as a barometer for criminal justice policy. Of all homicides committed, however, only some lead to arrest, to prosecution and ultimately to conviction in court.
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for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Anthony Brown
Science
brown@strw.leidenuniv.nl | +31 71 527 5884
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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Lessons from the Past for the Financial System of the Future
Lodewijk Petram, author of the book 'The World's First Stock Exchange', discussed the rise of the Amsterdam stock exchange in the 17th century in the ninth Hazelhoff Guest Lecture.
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Femke Stad
Faculteit der Sociale Wetenschappen
f.e.stad@fsw.leidenuniv.nl | +31 71 527 6790
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Francesco Buda
Science
f.buda@lic.leidenuniv.nl | +31 71 527 5723
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Marcellus Ubbink
Science
m.ubbink@chem.leidenuniv.nl | +31 71 527 4628
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Dirk-Jan Kok
Science
d.d.kok@cml.leidenuniv.nl | +31 71 527 2727
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Pam ten Broeke
Faculteit der Sociale Wetenschappen
p.ten.broeke@fsw.leidenuniv.nl | +31 71 527 2727
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Myfel Paluga
Faculteit der Sociale Wetenschappen
m.d.paluga@fsw.leidenuniv.nl | +31 71 527 3451
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Mike Slootweg
Science
h.j.slootweg@cml.leidenuniv.nl | +31 71 527 2727
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Measuring sustainability: an elaboration and application of the system of environmental-economic accounting for Indonesia
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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Schistosoma mansoni Extracellular Vesicles and their Impact on the Immune System
PhD defence
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Systemic sclerosis: from unravelling the impact of smoking to exploring new views on treatment strategies
PhD defence
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breast cancer cell-intrinsic mechanisms that manipulate the immune system
PhD defence
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Improving Side-effects and Quality of Life of Systemic Therapy in Oncology
PhD defence
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Guide for prospective students
If you are interested in studying stochastics, the following information will help you to choose the right path.
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Revealing the origins of solar systems: examining the formation of proto-planetary disks and binary stars
What is the origin of solar systems?
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Research
SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.
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The phonological systems of the Mbam languages of Cameroon with a focus on vowels and vowel harmony
The languages of the Mbam-et-Inoubou District of the Centre Region of Cameroon have a unique position in Bantu linguistics. Being in between
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and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical System in Pirgos and Praitoria for Community Health Development in Rural Crete
Promotor: Prof.dr. L.J. Slikkerveer
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the study of physics: An investigation of physics teachers' belief systems about teaching and learning physics
This doctoral thesis comprises four studies on the content and structure of physics teachers’ belief systems about teaching and learning physics in secondary education in the Netherlands.
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Joost Beltman
Science
j.b.beltman@lacdr.leidenuniv.nl | +31 71 527 4323