1,694 search results for “single molecule spectroscopy” in the Public website
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Lina Bayona Maldonado
Science
l.m.bayona.maldonado@biology.leidenuniv.nl | +31 71 527 4791
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Nicola Thome
Science
n.u.thome@biology.leidenuniv.nl | +31 71 527 4395
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Marcel Schaaf
Science
m.j.m.schaaf@biology.leidenuniv.nl | +31 71 527 4975
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Alireza Mashaghi Tabari
Science
a.mashaghi.tabari@lacdr.leidenuniv.nl | +31 71 527 4425
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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Metabolic Characterization of Marine Sponge
Which metabolites of sponge are influenced by individual environmental or biological factors?
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Leiden scientists develop topological barcodes for folded molecules
The team of Alireza Mashaghi at the Leiden Academic Centre for Drug Research has found a way to determine and classify the shape of proteins. Their new theory defines the topology of proteins as a simple and precise barcode that allows the identification of all types of folds. ‘This barcode enables…
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Determining the structure of a chemotaxis kinase complex with receptor mimetics and cryo-EM
Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?
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Biophysicists unravel exact folding of a single gene
The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.
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A metabolomics resistance test
Can metabolomic profiling be used to predict resistance against insect herbivores in plants?
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Small molecule prevents tumour cells from spreading
Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
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Going accurate for molecule – metal surface interactions
Researchers from the THEOR CHEM group at Leiden University strive to set new benchmarks in the accuracy of the prediction of interaction energies between molecules and metal surfaces.
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Football molecule explains 100-year-old astronomical problem
Exactly a century ago, astronomers observed the first two diffuse interstellar bands (DIBs) in space. A DIB manifests itself as a colour of light that is missing in the radiation from stars behind an interstellar cloud. Although about 500 DIBs are yet discovered, they remained inexplicable until recently.…
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Quantum Matter and Optics
The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.
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Fatema Zahra Rashid
Science
f.z.m.rashid@lic.leidenuniv.nl | +31 71 527 2727
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New quantum computer design to predict molecule properties
The standard approach to build a quantum computer with Majoranas as building blocks is to convert them into qubits. However, a promising application of quantum computing—quantum chemistry—would require these qubits to be converted again into so-called fermions. Physicists from Leiden and Delft suggest…
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spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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Leiden physicists detect single nanoparticles in motion
It's pretty hard to spot a single 5 nanometer particle. Leiden physicists pulled it off by turning a 120 nm gold rod into a detector.
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Physicist Michel Orrit new member KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit.
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…
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Operando research in electrochemistry
The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…
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Molecular inheritance from cloud to disk: a story of complex organics and accretion shocks
Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Michel Orrit and Hermen Overkleeft members KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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From intracluster medium dynamics to particle acceleration
The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.
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Catalysis of the electrochemical water oxidation to oxygen
Promotor: M.T.M. Koper, Co-Promotor: F. Calle-Vallejo
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Natural deep eutectic solvents: A new green solvent from nature
- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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Unlocking the potential of small molecules in cancer therapy
How can we translate more fundamental discoveries into clinical solutions for patients? From that question, the Oncode Accelerator programme emerged. Professor of Molecular Physiology Mario van der Stelt has been one of the driving forces behind it since its inception. In an interview on the website…
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Gas-surface reaction dynamics and surface science
The local ordering of atoms at the surface of a metallic particle determines its catalytic activity and selectivity. As energy systems of the future will be based on efficient catalytic conversion of small molecules in closed cycles, we study how structural effects of catalysts can be used to our ad…
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NMR Facility
Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…
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Quest for new antibiotics
Gubbens
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…