68 search results for “toxicology” in the Public website
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Fan Zhang
Science
f.zhang@cml.leidenuniv.nl | +31 71 527 5615
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Philipp Kropf
Science
p.kropf@cml.leidenuniv.nl | +31 71 527 2727
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Rudaz Serge
School of pharmaceutical sciences, University of Geneva - Switzerland
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Imke Bruns
Science
i.b.bruns@lacdr.leidenuniv.nl | +31 71 527 6039
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Surendra Balraadjsing
Science
s.balraadjsing@cml.leidenuniv.nl | +31 71 527 2727
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Contact
Contact
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Barrier properties of an N/TERT based human skin equivalent
Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.
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Christian Tudorache
Science
c.tudorache@biology.leidenuniv.nl | +31 71 527 4759
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Michael Richardson
Science
m.k.richardson@biology.leidenuniv.nl | +31 71 527 5215
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Risks to Health and the Environment Related to the Use of Lead in Products
The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.
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What is the effect of long-term exposure to engineered nanomaterials (ENMS)?
Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.
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Collaborations
Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).
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Pharmacy
The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Magnetic Resonance Imaging of the Adult Zebrafish
Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…
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Modelling the interactions of advanced micro- and nanoparticles with novel entities
Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.
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Horizon2020 grant for toxicologist Bob van de Water
An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.
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Giulia Callegaro
Science
g.callegaro@lacdr.leidenuniv.nl | +31 71 527 6105
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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High-throughput screening for developmental and reproductive toxicity
Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
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Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
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Industrial Pharmacy (MSc)
The master’s specialisation Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical industry.
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Bio-Pharmaceutical Sciences (MSc)
The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.
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Bio-Pharmaceutical Sciences and Education (MSc)
The master’s specialisation Bio-Pharmaceutical Sciences and Education at Leiden University combines fundamental chemistry research with an excellent education in becoming a Chemistry teacher.
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Bio-Pharmaceutical Sciences and Science Communication and Society (MSc)
The master’s specialisation Bio-Pharmaceutical Sciences and Science Communication & Society at Leiden University is a two-year programme which combines research training in chemistry with one in techniques of communication.
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Bio-Pharmaceutical Sciences and Business Studies (MSc)
The master’s specialisation Bio-Pharmaceutical Sciences and Business Studies at Leiden University combines fundamental and applied research with different aspects of business studies.
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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Marije Niemeijer
Science
m.c.niemeijer@lacdr.leidenuniv.nl | +31 71 527 6105
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Nanoplastics found throughout the human body – how worried should we be?
The world is becoming clogged with plastic, with tiny plastic particles found everywhere, from the oceans’ depths to the mountain tops, soil, plants, animals and even inside us. The question is: what harm, if any, are they causing? In a new article on The Conversation, environmental scientists Meiru…
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Publications
Recent publications
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Key publications
Key publications of the Quantitative Clinical Pharmacology group
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Key publications
Key publications of the Quantitative Pharmacology group
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Pesticides Atlas, Pilot Study
Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
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Extreme obesity demands tailor-made medication
Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.
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Animal-free chemical safety testing with new technology ToxProfiler
Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…
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Prof. dr. W. Jiskoot listed in Thomson Reuters 2015 Highly Cited Researchers
The list of highly Cited Researchers identifies the world’s most influential contemporary researchers across 21 scientific fields. Prof. dr. W. Jiskoot is cited one out of three in the field of Pharmacology & Toxicology in the Netherlands, and as one of four of all categories in Leiden.
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Bob van de Water
Science
water_b@lacdr.leidenuniv.nl | +31 71 527 6223
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…