2,882 search results for “modelling ” in the Public website
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Niki van Stein
Science
n.van.stein@liacs.leidenuniv.nl | +31 71 527 2727
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Peter van Bodegom
Science
p.m.van.bodegom@cml.leidenuniv.nl | +31 71 527 7486
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Matthijs van Leeuwen
Science
m.van.leeuwen@liacs.leidenuniv.nl | +31 71 527 7048
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Md Faysal Tareq
Science
m.f.tareq@cml.leidenuniv.nl | +31 71 527 2727
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Huub de Groot
Science
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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Nuno De Mesquita César de Sá
Science
n.q.de.mesquita.cesar.de.sa@cml.leidenuniv.nl | +31 71 527 2727
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Baoxiao Liu
Science
b.liu@cml.leidenuniv.nl | +31 71 527 5615
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Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Human DNA softer than DNA single-celled life
Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.
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Young Star Renske Donkers: how is she doing now?
How is Young Star Renske Donkers doing now? Early this year she was the second person ever to win the Young Star Award for the best bachelor student. After her bachelor Molecular Science & Technology, Renske is now busy with her master Chemical Process Engineering in Delft. ‘This award was a great boost…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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How do you determine the right medicine dosage for a child?
What’s the right dosage of medication for children? Assistant professor Elke Krekels and her colleagues discovered that for some medicines, you can determine this quite simply. On 13 April Krekels received the TOP-Publication award during the annual spring meeting of the Dutch Society for Clinical Pharmacology…
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Models Combination in Multi-stage Information Retrieval Architectures
Lecture
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Do we have a standard model of cosmology?
Lecture, Oort lecture
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Computational Biology Modeling with Tree Search and Learning
Lecture
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Statistical modelling of time-varying covariates for survival data
PhD defence
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Improving immunotherapy for melanoma: models, biomarkers and regulatory T cells
PhD defence
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Learning Unkown Intervention Targets in Structural Causal Models
Lecture
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Proof techniques in the quantum random-oracle model
PhD defence
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Aged human osteochondral explants as biomimetic osteoarthritis model
PhD defence
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Cochlear Implants: Bridging the gap between computational model and clinic
PhD defence
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Improving survival prediction models for liver transplantation candidates
PhD defence
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The parabolic Anderson model on Galton-Watson trees
PhD defence
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Staging cerebral amyloid angiopathy: From marker to model
PhD defence
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Van Marum Colloquium - Model Perovskite Oxide Electrocatalyst Surfaces
Lecture
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‘Investment risk is holding back energy transition’
The present market regulations make it extremely risky to invest in green energy, and this is impeding the fight against climate change. This is what Oscar Kraan writes in his dissertation. PhD defence on 25 April.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Laboratories for Digital Archaeology
The Digital Archaeology research group manages two computer laboratories with different purposes: the teaching lab (F1.01) and the research lab (A1.13a).
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Mathematics-based strategies for repairing tumour blood vessels
How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?
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Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
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Virtual children help prevent withdrawal syndrome in real children
When children wean off from heavy medication, they often experience withdrawal symptoms. The severity of these symptoms is often difficult to predict. Pharmacologist Bas Goulooze developed a computer model to determine the best weaning strategy for each child. His research has now been published in…
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Interdisciplinary approach benefits brain research
How do practice and theory reinforce one another in neuroscience? Professor Birte Forstmann’s inaugural lecture on 2 October will be about building interdisciplinary bridges between cognitive neuroscience and cognitive models. Her approach may lead to brain research with fewer side-effects for patie…
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HURP: Helsinki Urban Rat Project
How humans and rats cohabit the cityscape and what consequences this has for both sides of the conflict?
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Gibbs-non-Gibbs transitions and vector-valued integration
Promotor: W. T. F. den Hollander, F. H. J. Redig
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.