1,971 search results for “cancer drug resistance” in the Public website
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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New resource for the modelling community
The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…
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New professor wants to improve care for sarcoma patients
Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…
- Research
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Quantitative Clinical Pharmacology
The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…
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Laura Heitman nominated for Prix Galien
Laura Heitman of the Leiden Academic Center for Drug Research (LACDR) has been nominated for the Prix Galien Research Award. This important pharmaceutical prize honors young, prominent researchers whose scientific research is of great importance for fundamental or clinical drug research.
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Nathaniel Martin in de Volkskrant about toilets in space
German scientists and NASA have developed a bacteria-killing coating for space toilets. With this coating they hope to protect astronauts in space stations from pathogens. Professor of Biological chemistry Nathaniel Martin sheds light on the discovery: 'You don't expect nasty bacteria up there, but…
- Facilities
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Robert Rissmann appointed professor of Translational Dermatology at LACDR-CHDR
Pharmacist-clinical pharmacologist Robert Rissmann has been appointed Professor of Translational Dermatology. This extraordinary professorship has been created jointly by the Leiden Academic Centre for Drug Research (LACDR) and the Centre for Human Drug Research (CHDR) to strengthen their partnership…
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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Molecular precision Surgery: technical innovations and their relation to interactive perception
PhD defence
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Education
Our educational programmes span the entire spectrum of pharmaceutical education, from training of the next generation drug researchers in the areas of drug design, drug action, and drug use to educating the pharmacists of the future.
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Quality assessment and multi modalty in gastric cancer treatment
PhD defence
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Refining individualized treatment in older patients with breast cancer
PhD defence
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barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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Regulation of TGF-β signaling and EMT in cancer progression
PhD defence
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The tumor-stroma ratio in epithelial cancer types
PhD defence
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Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
PhD defence
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Early Detection of Pancreatic Cancer in High-Risk Individuals
PhD defence
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Understanding the complexity of TGF-beta signaling in cancer
PhD defence
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Characterization of candidate genes in unexplained polyposis and colorectal cancer
PhD defence
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Unraveling mucin type o-glycosylation signatures of colorectal cancer
PhD defence
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Towards personalized treatment for high risk endometrial cancer
PhD defence
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Optimizing immunotherapy in locoregional and metastatic urothelial cancer
PhD defence
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Diagnostic challenges of today's lung cancer pathology
PhD defence
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Management and priorities of older patients with multimorbidity and cancer
PhD defence
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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History
Life Sciences Artificial Intelligence Data Science
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Indira Nederpelt wins Young Investigator Award
Indira Nederpelt was elected as the winner of the Young Investigator Award for best oral presentation titled ‘’Kinetic characterization of clinically used GnRH peptide agonists’’.
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Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
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Bio-Pharmaceutical Sciences (BSc)
As a student of Bio-Pharmaceutical Sciences, you have a strong interest in drug development: from the onset of diseases to the effects of individual drugs in the body. Is that true for you? Then, Bio-Pharmaceutical Sciences might be the right study programme for you!
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Two KWF grants for LUMC on AI for precision oncology
This week, the Dutch Cancer Foundation (KWF) has awarded two research grants to LUMC researchers that include the development of advanced AI technology to improve and personalize oncological treatment.
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Programme structure
The Drug Discovery and Safety specialisation consists of compulsory and optional components.
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Lecture: Chemical Probes for imaging and analysis of hydrolase function in Cancer, Infectious Diseases and the microbiome
Lecture
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Chemistry research for better chemotherapy Finalist PNAS paper award
Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.
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Steffen Brünle
Science
s.bruenle@lic.leidenuniv.nl | +31 71 527 4544
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New antibiotic named after Leiden
Increasing resistance and a lack of new antibiotics are a serious problem for public health. Against this background, Gilles van Wezel of the Institute of Biology Leiden is looking for new medicines. Together with former PhD student Changsheng Wu and colleagues he discovered the special antibiotic lugdunomycin,…
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Glyco(proteo)mic Workflows for Cancer Biomarker Discovery
PhD defence
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About the programme
Master International Relations specialisation Culture and Politics.
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R-ELEVATION
How do plant defense genes get activated?
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Plant Sciences
The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…
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Key publications
Key publications of the Antiviral Pharmacology group.
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Imaging functional brain connectivity: pharmacological modulation, aging and Alzheimer's disease
Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.