2,208 search results for “war on drugs” in the Public website
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A war of words: What ancient Manchurian history does to Korea and China today
Why does the past elicit this intense activity in the present? What does the past mean for the present, and what does it do to it? A WAR OF WORDS will engage this complex of Chinese claims to Manchu-Korean ancient history, South Korean reactions, public discourse and cultural expression in both states,…
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Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
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Humour and Irony in Dutch Post-war Fiction Film, Peter Verstraten
If Dutch cinema is examined in academic studies, the focus is usually on pre-war films or on documentaries, but the post-war fiction film has been sporadically addressed.
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Words and Laments: A Narratological Analysis of Esmāʻil Fasih’s War Novel, The Winter of 1983 (Zemestān-e 62)
Saeedeh Shahnahpur defended her thesis on 13 September 2016.
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Marginalized Groups, Inequalities and the Post-War Welfare State
This book offers novel perspectives on the national and international dimensions of the post-war welfare state in Western Europe and North America.
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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Crisis and Security Management: War and Peace Studies (MSc)
Are you thinking about studying Crisis and Security Management: War and Peace Studies? Learn more and watch the videos.
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Memory Wars in the Low Countries, 1566-1700
The Revolt in The Netherlands erupted in 1566 and tore apart the Low Countries. In Memory Wars in the Low Countries, 1566-1700 Jasper van der Steen explains how public memories of the Revolt in the Habsburg Netherlands in the South and the Dutch Republic in the North diverged and became the objects…
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Promoting Accountability for War Crimes: Should UN Peacekeepers be involved?
Tom Buitelaar is an Assistant Professor in the War, Peace & Justice programme of the Institute of Security and Global Affairs. This paper discusses four important challenges to the involvement of UN peace operations in international criminal justice: its effects on host state relations, peace and justice…
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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a Hard Place: The Precarious State of a Double Agent during the Cold War
In this article, Ben de Jong, research fellow at the Institute of Security and Global Affairs, examines the relationship between double agents and their handlers.
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The Lives Of Cold War Afro-Asianism
The Afro-Asianism of the early Cold War has long remained buried under the narrative of Bandung, homogenising and subverting the different visions of post-colonial worldmaking that co-existed alongside the Bandung project.
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Japan's Occupation of Java in the Second World War
Japan's Occupation of Java in the Second World War draws upon written and oral Japanese, Indonesian, Dutch and English-language sources to narrate the Japanese occupation of Java as a transnational intersection between two complex Asian societies, placing this narrative in a larger wartime context of…
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Forces and Innovations in Security Governance in Mozambique’s Civil War
Political scientist Corinna Jentzsch (Leiden University) about the organisation of rebel and government auxiliaries in the civil war in Mozambique (1976–1992).
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Monitoring drug-related homicides: An assessment of existing data sources and potential for future monitoring
This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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namic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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generation human IPSC-derived reporter systems for image-based analysis of drug adversity
Analysis of drug adversity
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Pharmacodynamics of analgesics and sedatives in neonates and infants
In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.
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Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Hildert Bronkhorst
Science
h.bronkhorst@biology.leidenuniv.nl | +31 71 527 4964
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A community effort to assess and improve drug sensitivity prediction algorithms
Source: Nature Biotechnology, Volume 2014, Issue June (2014)
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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throughput microscopy for cellular adaptive stress response pathways in drug adversity
High throughput microscopy
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Global Perspectives on the Bretton Woods Conference and the Post-War World Order
The historiography of the Bretton Woods conference of July 1944 is dominated by the personal clash between the principal negotiators, Harry Dexter White of the United States and John Maynard Keynes of Britain.
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Empire's Violent End. Comparing Dutch, British, and French Wars of Decolonization, 1945-1962
In the last two decades, there have been heated public and scholarly debates in France, the United Kingdom, and the Netherlands on the violent end of empire. Nevertheless, the broader comparative investigations into colonial counterinsurgency tend to leave atrocities such as torture, execution, and…
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Gerard van Westen: 'Our model predicts what candidate drugs do in your body'
He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst
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The Egyptian Labor Corps: Race, Space, and Place in the First World War
This book talk will be hosted on Thursday, 27 June 2024 at 6:00 pm.
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Secret Intelligence and Public Diplomacy in the Ukraine War
In this article, Thomas Maguire, Assistant Professor at the Institute of Security and Global Affairs, examines why states use intelligence to influence external audiences.
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quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Polypept(o)ide-based Cylindrical Polymer Brushes as Multifunctional Drug Delivery Systems
The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Open-source research and the war in Ukraine: intelligence for the people by the people?
Who are open-source intelligence activists and how reliable are their contributions to public understanding of Russia’s war in Ukraine?
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War, Entrepreneurs, and the State in Europe and the Mediterranean, 1300-1800
This edited volume by Jeff Fynn-Paul pushes forward the debate on the role of entrepreneurs in making war and building states in Europe and the Ottoman Empire.
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Evani Lachmansingh
Science
e.t.lachmansingh@liacs.leidenuniv.nl | +31 71 527 2727
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Alexander Kros
Science
a.kros@chem.leidenuniv.nl | +31 71 527 4234
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Beyond the Pale: Dutch Extreme Violence in the Indonesian War of Independence, 1945-1949
On 17 August 1945, two days after the Japanese surrender that also brought an end to the Second World War in Asia, Indonesia declared its independence. The declaration was not recognized by the Netherlands, which resorted to force in its attempt to take control of the inevitable process of decolonization.…
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Early modern war narratives and the Revolt in the Low Countries
By the end of the sixteenth century, stories about the Revolt in the Low Countries (c. 1567-1648) had begun to spread throughout Europe. These stories had very different authors with very different intentions.