2,268 search results for “single molecule spectroscopy” in the Public website
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stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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enhancement of one-photon- and two-photon-excited single-molecule fluorescence by single gold nanorods
This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.
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Low-temperature spectroscopic studies of single molecules in 3-D and on 2-D hosts
Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Michel Orrit Lab - Single Molecule Optics
Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.
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Towards Optical Detection of a Single Electron
Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Electronic spectroscopy of molecules of astrophysical interest
This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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Michel Orrit
Science
orrit@physics.leidenuniv.nl | +31 71 527 2727
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Optoplasmonic detection of single particles and molecules in motion
Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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Applications of paramagnetic NMR spectroscopy for protein research
The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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to study transcription factor binding to chromatin at the single-molecule level
Science, Leiden Institute of Physics (LION)
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Fluorescence Correlation Spectroscopy on Electron Transfer Reaction: Probing Inter- and Intramolecular Redox Processes
Promotores: G.W. Canters, T.J. Aartsma
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Thomas Schmidt Lab - Single Molecule Microscopy
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
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Infrared spectroscopy of astrophysically relevant hydrocarbons
This thesis is about the study of hydrocarbons via infrared spectroscopy.
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luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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High-resolution integral-field spectroscopy of exoplanets
This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.
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Pushing the envelope of nuclear magnetic resonance spectroscopy for paramagnetic systems
A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…
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X-ray spectroscopy of merging galaxy clusters
This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.
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Visualising the nanoworld
Visualising cell proteins without invasive techniques is possible with the help of fluorescence. During a lecture of the Natuurwetenschappelijk Gezelschap Leiden on 18 January, winner of the Spinoza Prize 2017 and founder of the field of single molecule optics Michel Orrit explained how this works.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Amin Moradi
Science
moradi@physics.leidenuniv.nl | +31 71 527 2727
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Plasmonic enhancement of single-molecule fluorescence under one- and two-photon excitation
This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…
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SDS-PAGE at the nanoscale: A nanorecorder for single molecule protein sequencing with graphene
Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?
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High-contrast spectroscopy of exoplanet atmospheres
More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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Large media attention for Spinoza Prize Michel Orrit
An important award like the Spinoza Prize, the 'Dutch Nobel Prize', generates lots of media attention. An overview.
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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The hunt for frozen organic molecules in space
Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.
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Michel Orrit wins Physica Prize 2016
Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.
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Michel Orrit receives Spinoza Prize in Royal Theatre
On September 12, Michel Orrit received his Spinoza prize in the Royal Theatre in The Hague from OCW Secretary of State Sander Dekker. With the award comes a budget of 2.5 million euro, to be spent freely on scientific research, and the coveted Spinoza statue. Orrit shared the honor with Eveline Crone…
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Protein motions revealed by paramagnetic NMR spectroscopy
Hass
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Spectroscopy of two-field inflation
This thesis is about cosmological inflation and its relation to observations.
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Bioactive Molecules
Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.
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PhD defence livestream
On this page you can follow PhD defences by Leiden University researchers via videostream.
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Single molecules show promise to optically detect single electrons
Optical detection of a single electron using a single molecule has never been done. Leiden physicist Michel Orrit and his team have now identified a molecule that is sensitive enough to detect an electron at a distance of hundreds of nanometers. The results are published as a cover article in ChemPh…
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Long-Term Observation of Protein Dynamics via Thermal-Snapshot Single Molecule Spectroscopy
PhD defence
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Single life and the city
Ariadne Schmidt, Isabelle Devos and Julie de Groot provide you with refreshing insights concerning the study on urban singles in the period between 1200 and 1900.
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Spinoza Prize for Michel Orrit, Professor of Spectroscopy
It is partly thanks to Leiden professor Michel Orrit that we are today able to study individual molecules. He just missed winning a Nobel Prize, but is today the recipient of another important scientific award: NWO’s prestigious Spinoza Prize.
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Single Supervision, Single Judicial Protection?
On 14 December, Jouke Tegelaar defended the thesis 'Single supervision, single judicial protection? Towards effective judicial protection in Single Supervisory Mechanism composite procedures'. The doctoral research was supervised by Matthias Haentjens and Willemien den Ouden.
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Classical and paramagnetic NMR spectroscopy applied to different protein systems
Promotor: Prof.dr. M. Ubbink
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Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
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Exploring strange new worlds with high-dispersion spectroscopy
Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…
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the hot Universe: Advances and challenges in high-resolution X-ray spectroscopy
Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.