71 search results for “bioactive molecules” in the Public website
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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Plant Latex: A Potential Resource of Bioactive Chemicals
How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?
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Advanced Pre-clinical Evaluation of the Guanidino Lipoglycopeptides: A Novel Family of Glycopeptide Antibiotics with Best-in-Class Potential
Can we make a better vancomycin?
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Improving the filamentous fungus Aspergillus niger as cell factory for starch degrading enzymes
We aim to develop A. niger strains that produce more starch degrading enzymes even in the absence of starch.
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Natural deep eutectic solvents: A new green solvent from nature
- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?
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Lina Bayona Maldonado
Science
l.m.bayona.maldonado@biology.leidenuniv.nl | +31 71 527 4791
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Nicola Thome
Science
n.u.thome@biology.leidenuniv.nl | +31 71 527 4395
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Biotransformation of plant metabolites in microorganisms
- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Quest for new antibiotics
Gubbens
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IBL Spotlights - Bioactive molecules
Lecture
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The role of auxin in somatic embryogenesis
What is the role of auxin in the initiation and process of somatic embryogenesis?
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Screening of animal venoms for antimicrobial compounds
Can animal venoms yield novel antimicrobial peptides?
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines
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Metabolic Characterization of Marine Sponge
Which metabolites of sponge are influenced by individual environmental or biological factors?
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Manipulating plant metabolomic profiles by seed and plant cutting treatments to enhance plant protection against western flower thrips
How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…
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SKY HIGH: Vertical farming a revolution in plant production
As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.
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Determining the structure of a chemotaxis kinase complex with receptor mimetics and cryo-EM
Can we determine the 3D structure of a chemotaxis core complex using single-particle reconstructions via cryo-EM?
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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Harnessing the soil microbiome for improved stress tolerance in crop plants
Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?
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Arthur Ram receives NWO grant to improve enzyme factory
This year, microbiologist Arthur Ram will start new research on producing useful enzymes in bulk. Ram receives an NWO grant for this project that will find its applications in the industrial biotechnology and food industry.
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Rob Verpoorte receives prestigious pharmocognosy award
The American Society of Pharmacognosy (ASP) has given the Varro E. Tyler prize to Rob Verpoorte, for his outstanding lifetime contributions to the science of nature as source of medicine.
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Targeted biomolecule production for therapeutic use
We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.
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From methanol to medicine – Sustainable microbial production of polyketide antibiotics
Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?
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A metabolomics resistance test
Can metabolomic profiling be used to predict resistance against insect herbivores in plants?
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The evolution of the diversity of secondary metabolites
Why do plants produces always produced so many slightly differing metabolites within a particular chemical class?
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Flower bulbs to treat Alzheimer's
The substance galanthamine from flower bulbs can fight symptoms of Alzheimer's disease. Nadeem Akram investigated how daffodils can optimally produce this natural remedy. PhD defence on 24 June.
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ERC grant to further investigate next-generation antibiotics with reduced toxicity
The European Research Council (ERC) has awarded Nathaniel Martin a Proof of Concept (PoC) grant. With it, his group aims to make a dangerous but potent antibiotic less toxic. He receives €150.000.
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Luis Salome Abarca about plant chemicals and the Hortus botanicus
What chemicals do plants have available, and what happens if they use them when faced with bacteria or fungi? That is what PhD candidate Luis Salomé Abarca is keen to learn. He studies plants’ survival and their use of chemical components in communication and defence. Salomé Abarca works at the Natural…
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Annemarie Meijer
Science
a.h.meijer@biology.leidenuniv.nl | +31 71 527 4927
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Greenifying industrial biotechnology through the creation of synthetic endosymbionts
Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?
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The role of 14-3-3 proteins in ion homeostasis in the yeast Saccharomyces cerevisiae
We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Snake venom glands grown in lab
For the first time, researchers were able to grow organoids from snake venom glands. The lab-grown 3-D structures can produce snake venom molecules. This is a major step in finding treatments to tackle snakebite, which causes over 100,000 deaths each year. Publication in top journal Cell.
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NWO grant gives way to more sustainable production of antibiotics
The opportunity to explore a new, exciting research topic. That is how Lennart Schada von Borzyskowski describes his successful application for the NWO XS grant. It comprises 50,000 euros, which the researcher from the Institute of Biology Leiden (IBL) will spend on investigating a more sustainable…
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Discovery Leiden nominated for KIJK: Best Tech-idea of 2021
Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.
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Altruism in bacteria: colonies divide the work
Bacteria found in soil specialise in the colony by division of labour. Some of the bacteria produce antibiotics, even when it comes at the expense of their individual reproduction success, to defend their colony against competitors. Publication in Science Advances.