The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

What is the role of stress and stress-related hormones in emotion regulation?

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.

Does a universal psychoeducational course about stress in adolescents: I) lead to an increase in knowledge of stress?, II) affect the frequency with which stressors are experienced and the overall stress level?, III) create interest in a tier 2 level follow-up training?, and IV) appeal to students in…

Being a student can be stressful. Study pressure, living on your own, moving country, financial stress: things can be difficult. Unexpected difficulties may lead to study delay.

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

What is the effectiveness of two school-based skills-training programs in promoting mental health?

Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…

Can epigenetic changes explain associations between early life stress and health outcomes?

How can we facilitate the early recognition of stress and anxiety in the classroom and collaborate with schools in providing low-threshold interventions?

The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Promotor: B. van de Water

What role play stress and fear in forming of nocebo hyperalgesia?

Promotor: Prof.dr. J. Kuiper

What are the behavioral, cognitive, and motivational consequences of decision reversibility?

To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…

High throughput microscopy

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Our vision of stress is starting to change fundamentally. We can suffer stress without even being aware of it, while sleeping as wall as during the day. Professor of Psychology Jos Brosschot will discuss this phenomenon in his inaugural lecture on 2 December.

Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column

Stress, burnout, depression – these conditions pervade all levels of our society. Children and students suffer from constant pressure to achieve; at the international level, tensions lead to short-sighted actions; and, at the personal level, stress affects our health and social environment. How do our…

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?

Recent studies have shown that Dutch secondary school pupils experience a great deal of stress from school work, and between 2001 and 2007 the number of adolescents experiencing school stress even doubled. The study carried out by Simone Vogelaar focuses on stress factors and the effectiveness of the…

The challenge: Building a tool to detect chemical compounds that individually cause non-lethal stress to bacteria, but that are lethal in combination. A team of thirteen Leiden students are taking up this challenge in the annual ‘international Genetically Engineered Machine’ (iGEM) competition for applications…

Clinical psychologist Bernet Elzinga has been appointed as Professor of a personal chair at the Faculty of Social and Behavioural Sciences. This professorship will contribute both nationally and internationally to the broader promotion of Leiden University in the field of stress and psychopathology.